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1/13/2020 11:27:13 AM | Browse: 28 | Download: 6
Publication Name World Journal of Gastroenterology
Manuscript ID 51872
Country of Manuscript Source China
Received
2019-10-08 03:16
Peer-Review Started
2019-10-08 03:16
To Make the First Decision
Return for Revision
2019-11-10 05:19
Revised
2019-12-14 04:03
Second Decision
2019-12-19 06:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-12-23 10:11
Articles in Press
2019-12-23 10:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-05 10:09
Typeset the Manuscript
2020-01-10 08:45
Publish the Manuscript Online
2020-01-13 11:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Observational Study
Article Title Impact of reactivation of the GFRA1 gene by DNA demethylation on the prognosis of patients with metastatic colon cancer
Manuscript Source Unsolicited Manuscript
All Author List Wan-Ru Ma, Peng Xu, Zhao-Jun Liu, Jing Zhou, Lian-Kun Gu, Jun Zhang and Da-Jun Deng
ORCID
Author(s) ORCID Number
Wan-Ru Ma http://orcid.org/0000-0002-9697-7355
Peng Xu http://orcid.org/0000-0002-7559-8559
Zhao-Jun Liu http://orcid.org/0000-0003-0924-7862
Jing Zhou http://orcid.org/0000-0001-9814-6574
Lian-Kun Gu http://orcid.org/0000-0003-0791-1280
Jun Zhang http://orcid.org/0000-0001-9796-994X
Da-Jun Deng http://orcid.org/0000-0001-5161-5943
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China A3 Foresight Program 31261140372
Beijing Science and Technology Commission Z151100001615022
the Science Foundation of Peking University Cancer Hospital 2017-25
Corresponding author Da-Jun Deng, MD, Professor, Laboratory of Carcinogenesis and Translational Research (MOE/Beijing), Division of Etiology, Peking University Cancer Hospital and Institute, Fu-Cheng-Lu #52, Haidian District, Beijing 100142, China. dengdajun@bjmu.edu.cn
Keywords GFRA1; Demethylation; CpG island; Colon cancer; Metastasis; Membrane receptor
Core Tip GFRA1 reactivation by DNA demethylation is a frequent event in colon cancer (CC) development and that the high level of GFRA1 demethylation in CC tissues is correlated with high metastasis risk of CC and shorter overall survival of patients, especially patients with metastatic CC. We find that GFRA1 overexpression enhances the proliferation and growth of CC cells in vitro and in vivo, probably by activation of the GFRA1-GDNF downstream pathway. These data indicate that reactivation of GFRA1 by DNA demethylation is an important prognosis factor for CC and the cancer-related cell membrane protein GFRA1 may be a therapeutic target for CC patients.
Publish Date 2020-01-13 11:27
Citation Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ. Impact of reactivation of the GFRA1 gene by DNA demethylation on the prognosis of patients with metastatic colon cancer. World J Gastroenterol 2020; 26(2): 184-198
Url https://www.wjgnet.com/1007-9327/full/v26/i2/184.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i2.184
Full Article (PDF) WJG-26-184.pdf
Full Article (Word) WJG-26-184.docx
Manuscript File 51872-Review_WangTQ.docx
Answering Reviewers 51872-Answering reviewers.pdf
Audio Core Tip 51872-Audio core tip.m4a
Biostatistics Review Certificate 51872-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51872-Conflict-of-interest statement.pdf
Copyright License Agreement 51872-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51872-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 51872-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 51872-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51872-Language certificate.pdf
Supplementary Material 51872-Supplementary material.pdf
Peer-review Report 51872-Peer-review(s).pdf
Scientific Misconduct Check 51872-Scientific misconduct check.pdf
Scientific Editor Work List 51872-Scientific editor work list.pdf