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2/14/2020 11:49:18 AM | Browse: 19 | Download: 15
Publication Name World Journal of Gastroenterology
Manuscript ID 52041
Country of Manuscript Source India
2019-10-15 09:51
Peer-Review Started
2019-10-15 09:52
To Make the First Decision
Return for Revision
2019-12-04 20:08
2019-12-20 12:39
Second Decision
2020-01-11 03:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-14 19:56
Articles in Press
2020-01-14 19:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-18 23:43
Typeset the Manuscript
2020-02-13 00:22
Publish the Manuscript Online
2020-02-14 11:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Basic Study
Article Title Histone deacetylase inhibitor pretreatment enhances efficacy of DNA-interacting chemo-drugs in gastric cancer
Manuscript Source Invited Manuscript
All Author List Ramchandra Vijay Amnekar, Shafqat Ali Khan, Mudasir Rashid, Bharat Khade, Rahul Thorat, Poonam Gera, Shailesh V Shrikhande, Duane T Smoot, Hassan Ashktorab and Sanjay Gupta
Author(s) ORCID Number
Ramchandra Vijay Amnekar http://orcid.org/0000-0003-2644-4016
Shafqat Ali Khan http://orcid.org/0000-0002-8573-792X
Mudasir Rashid http://orcid.org/0000-0001-9342-6243
Bharat Khade http://orcid.org/0000-0001-8099-2326
Rahul Thorat http://orcid.org/0000-0001-5059-0342
Poonam Gera http://orcid.org/0000-0001-7709-1594
Shailesh V Shrikhande http://orcid.org/0000-0002-8036-4212
Duane T Smoot http://orcid.org/0000-0002-8416-7419
Hassan Ashktorab http://orcid.org/0000-0002-4048-4666
Sanjay Gupta http://orcid.org/0000-0002-1209-189X
Funding Agency and Grant Number
Funding Agency Grant Number
TMH-IRG 466/2012 and 164/2016
Corresponding author Sanjay Gupta, PhD, Senior Scientist, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, Maharashtra, India. sgupta@actrec.gov.in
Keywords Chemotherapy; Combinatorial index; Gastric cancer; Histone acetylation; Histone deacetylase inhibitor; Patient stratification
Core Tip Our study suggest that pre-treatment with histone deacetylase inhibitors (HDACi) in a pre-clinical model of gastric cancer increase acetylation, opens chromatin and favors binding of DNA interacting chemotherapeutic drugs synergistically. This enhances cytotoxic potential of chemotherapeutic drug at low therapeutic dose and reduces toxicity. The dose response studies using Fa plots and median curve analysis proposes valproic acid as the most synergistic and effective HDACi in combination with platinum based drugs. Further, HDAC expression or activity based patient stratification prior to HDACi therapy has been put forth for better clinical outcome of chemotherapeutic drugs in solid tumors.
Publish Date 2020-02-14 11:49
Citation Amnekar RV, Khan SA, Rashid M, Khade B, Thorat R, Gera P, Shrikhande SV, Smoot DT, Ashktorab H and Gupta S. Histone deacetylase inhibitor pretreatment enhances efficacy of DNA-interacting chemo-drugs in gastric cancer. World J Gastroenterol 2020; 26(6): 598-613
Url https://www.wjgnet.com/1007-9327/full/v26/i6/598.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i6.598
Full Article (PDF) WJG-26-598.pdf
Full Article (Word) WJG-26-598.docx
Manuscript File 52041-Review-Filipodia.docx
Answering Reviewers 52041-Answering reviewers.pdf
Audio Core Tip 52041-Audio core tip.mp3
Biostatistics Review Certificate 52041-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52041-Conflict-of-interest statement.pdf
Copyright License Agreement 52041-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52041-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52041-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 52041-Language certificate.pdf
Supplementary Material 52041-Supplementary material.pdf
Peer-review Report 52041-Peer-review(s).pdf
Scientific Misconduct Check 52041-Scientific misconduct check.pdf
Scientific Editor Work List 52041-Scientific editor work list.pdf