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12/6/2019 8:06:37 AM | Browse: 778 | Download: 1241
Publication Name World Journal of Gastroenterology
Manuscript ID 52092
Country/Territory China
2019-10-16 08:54
Peer-Review Started
2019-10-16 08:54
To Make the First Decision
2019-11-04 07:38
Return for Revision
2019-11-05 02:33
2019-11-10 08:13
Second Decision
2019-11-22 13:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-22 22:37
Articles in Press
2019-11-22 22:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-25 05:23
Typeset the Manuscript
2019-12-04 07:52
Publish the Manuscript Online
2019-12-06 08:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway
Manuscript Source Unsolicited Manuscript
All Author List Xue-Yang Chen, Chang-Zhou Cai, Meng-Li Yu, Ze-Min Feng, Yu-Wei Zhang, Pei-Hao Liu, Hang Zeng and Chao-Hui Yu
Author(s) ORCID Number
Xue-Yang Chen http://orcid.org/0000-0002-2740-4772
Chang-Zhou Cai http://orcid.org/0000-0003-4602-5046
Meng-Li Yu http://orcid.org/0000-0002-1368-1242
Ze-Min Feng http://orcid.org/0000-0003-3419-0247
Yu-Wei Zhang http://orcid.org/0000-0002-4415-5595
Pei-Hao Liu http://orcid.org/0000-0003-3908-6342
Hang Zeng http://orcid.org/0000-0002-3140-0125
Chao-Hui Yu http://orcid.org/0000-0003-4842-3646
Funding Agency and Grant Number
Corresponding Author Chao-Hui Yu, MD, PhD, Chief Doctor, Doctor, Professor, Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zyyyych@zju.edu.cn
Key Words LB100; Nonalcoholic fatty liver disease; Serine/threonine-protein phosphatase 2A; Lipid metabolism; AMP-activated protein kinase α; Sirtuin 1
Core Tip Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, which greatly increases the medical and economic burden. We aimed to investigate the effect and underlying mechanism of LB100 in lipid accumulation during NAFLD development in mice fed a high fat diet and L02 cells treated with free fatty acids. Our study provided, for the first time, in vivo and in vitro evidence that LB100 can effectively inhibit hepatic lipogenesis via the AMPK/Sirt1 pathway and could be a therapeutic strategy for NAFLD.
Publish Date 2019-12-06 08:06
Citation Chen XY, Cai CZ, Yu ML, Feng ZM, Zhang YW, Liu PH, Zeng H, Yu CH. LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. World J Gastroenterol 2019;25(45): 6607-6618
URL https://www.wjgnet.com/1007-9327/full/v25/i45/6607.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i45.6607
Full Article (PDF) WJG-25-6607.pdf
Full Article (Word) WJG-25-6607.docx
The ARRIVE Guidelines 52092-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 52092-Review-Tracked.docx
Answering Reviewers 52092-Answering reviewers.pdf
Audio Core Tip 52092-Audio core tip.mp3
Biostatistics Review Certificate 52092-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52092-Conflict-of-interest statement.pdf
Copyright License Agreement 52092-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 52092-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 52092-Language certificate.pdf
Supplementary Material 52092-Supplementary material.pdf
Peer-review Report 52092-Peer-review(s).pdf
Scientific Misconduct Check 52092-Bing-Tang JZ-2.png
Scientific Misconduct Check 52092-Scientific misconduct check.pdf
Scientific Editor Work List 52092-Scientific editor work list.pdf