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Articles Published Processes
2/28/2020 10:08:51 AM | Browse: 904 | Download: 1355
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Received |
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2019-10-22 08:45 |
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Peer-Review Started |
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2019-10-22 08:45 |
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To Make the First Decision |
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2019-12-11 06:00 |
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Return for Revision |
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2019-12-11 09:46 |
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Revised |
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2019-12-17 13:47 |
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Second Decision |
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2020-02-14 11:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-02-14 22:36 |
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Articles in Press |
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2020-02-14 22:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-02-28 01:48 |
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Publish the Manuscript Online |
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2020-02-28 10:08 |
| ISSN |
2308-3840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Systematic Reviews |
| Article Title |
L-carnitine supplementation in non-alcoholic fatty liver disease: A systematic review and meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Prarthana Thiagarajan, Jane Chalmers, Lu Ban, Douglas Grindlay and Guruprasad P Aithal |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Prarthana Thiagarajan, MBBS, MRCP, Academic Fellow, National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, E Floor West Block Queens Medical Centre Derby Road, Nottingham NG7 2UH, United Kingdom. prarthana.thiagarajan@nottingham.ac.uk |
| Key Words |
L-Carnitine; Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Liver function; Insulin resistance; Meta-analysis |
| Core Tip |
Non-Alcoholic Fatty Liver Disease (NAFLD) presents a major public health challenge. As a leading cause of abnormal liver chemistry, rising in prevalence together with obesity and insulin resistance, there is critical unmet need to identify cost-effective, population-based treatment. We synthesised evidence from randomised trials published to date evaluating the effect of dietary L-carnitine supplementation on transaminases, liver fat and insulin resistance in NAFLD. We demonstrate a significant reduction in serum alanine aminotransferase, homeostasis model of insulin resistance and liver fat with dietary L-carnitine supplementation. L-carnitine could therefore present a novel therapeutic tool for NAFLD and its metabolic associations. |
| Publish Date |
2020-02-28 10:08 |
| Citation |
Thiagarajan P, Chalmers J, Ban L, Grindlay D, Aithal GP. L-carnitine supplementation in non-alcoholic fatty liver disease: A systematic review and meta-analysis. World J Meta-Anal 2020; 8(1): 4-14 |
| URL |
https://www.wjgnet.com/2308-3840/full/v8/i1/4.htm |
| DOI |
https://dx.doi.org/10.13105/wjma.v8.i1.4 |
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