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Publication Name World Journal of Gastroenterology
Manuscript ID 52257
Country of Manuscript Source China
2019-11-06 07:37
Peer-Review Started
2019-11-05 09:41
To Make the First Decision
Return for Revision
2019-12-07 04:23
2019-12-13 19:27
Second Decision
2019-12-30 06:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-01 22:54
Articles in Press
2020-01-01 22:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-01-13 19:27
Typeset the Manuscript
2020-02-06 02:41
Publish the Manuscript Online
2020-02-07 13:14
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Case Control Study
Article Title Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells
Manuscript Source Unsolicited Manuscript
All Author List Hong Zheng, Jin-Jing Wang, Xiao-Rong Yang and Yong-Lin Yu
Author(s) ORCID Number
Hong Zheng http://orcid.org/0000-0003-1868-4490
Jin-Jing Wang http://orcid.org/0000-0002-3955-2131
Xiao-Rong Yang http://orcid.org/0000-0002-7953-0420
Yong-Lin Yu http://orcid.org/0000-0002-7190-896X
Funding Agency and Grant Number
Corresponding author Hong Zheng, PhD, Chief Physician, Department of Pathology, The Affiliated Hospital of Zunyi Medical University, No.149, Dalian Road, Zunyi 563003, Guizhou Province, China. z5tff9l3@sina.com
Keywords E2F transcription factor 1; MicroRNA 34c; Gastric cancer; Paclitaxel combined with cisplatin resistance; ;
Core Tip Gastric cancer (GC) is one of the most common types of cancer. The molecular mechanism of GC is intricate, and understanding the molecular mechanism of drug resistance is helpful to improve the effect of chemotherapy. The mutual binding of miRNAs and transcription factors is closely related to the occurrence of cancer. In this study, it was found that E2F transcription factor 1 inhibited the transcription of miR-34c to promote the proliferation of GC cells, and enhance the resistance of paclitaxel combined with cisplatin. While silencing the expression of E2F transcription factor 1 in GC cells could improve the efficacy of paclitaxel combined with cisplatin.
Publish Date 2020-02-07 13:14
Citation Zheng H, Wang JJ, Yang XR, Yu YL. Upregulation of miR-34c after silencing E2F transcription factor 1 inhibits paclitaxel combined with cisplatin resistance in gastric cancer cells. World J Gastroenterol 2020; 26(5): 499-513
Url https://www.wjgnet.com/1007-9327/full/v26/i5/499.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i5.499
Full Article (PDF) WJG-26-499.pdf
Full Article (Word) WJG-26-499.docx
Manuscript File 52257-Review-Filipodia.doc
Audio Core Tip 52257-Audio core tip.mp3
Biostatistics Review Certificate 52257-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52257-Conflict-of-interest statement.pdf
Copyright License Agreement 52257-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 52257-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 52257-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52257-Language certificate.pdf
Supplementary Material 52257-Supplementary material.pdf
Peer-review Report 52257-Peer-review(s).pdf
Scientific Misconduct Check 52257-Scientific misconduct check.pdf
Scientific Editor Work List 52257-Scientific editor work list.pdf