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9/11/2014 8:39:00 PM | Browse: 781 | Download: 273
Publication Name World Journal of Gastroenterology
Manuscript ID 5228
Country/Territory Taiwan
Received
2013-08-24 08:19
Peer-Review Started
2013-08-24 10:07
To Make the First Decision
Return for Revision
Revised
2013-11-01 15:25
Second Decision
2013-11-13 10:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-13 14:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-12-12 19:29
Publish the Manuscript Online
2014-01-20 16:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Topic Highlights
Article Title Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List Chia-Chi Hsu, Hsin-Chen Lee and Yau-Huei Wei
Funding Agency and Grant Number
Funding Agency Grant Number
Grant for the Center of Excellence for Cancer Research at Taipei Veterans General Hospital from the Ministry of Health and Welfare of the Executive Yuan DOH102-TDC-111-007
the Aim for the Top University Plan of the Ministry of Education and National Science Council of Taiwan NSC101-2320-B-010-068-MY3
the Aim for the Top University Plan of the Ministry of Education and National Science Council of Taiwan NSC100-2320-B-010-024-MY3
Corresponding author Hsin-Chen Lee, PhD, Institute of Pharmacology, School of Medicine, National Yang-Ming University, No. 155, Li-Nong St., Sec. 2, Taipei 112, Taiwan. hclee2@ym.edu.tw
Key Words Hepatocellular carcinoma; Somatic mitochondrial DNA mutations; Mitochondrial dysfunction
Core Tip In this review, we summarize the recent findings on the somatic mtDNA alterations identified in hepatocellular carcinoma (HCC) and their relationships with the clinicopathological features of HCC. We suggest that somatic mtDNA mutations and a decrease in the mtDNA copy number are common events in HCC and that a mitochondrial dysfunction-activated signaling cascade may play an important role in the progression of HCC. Elucidation of the retrograde signaling pathways in HCC and the quest for strategies to block some of these pathways will be instrumental for the development of novel treatments for this and other malignancies.
Publish Date 2014-01-20 16:41
Citation Hsu CC, Lee HC, Wei YH. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J Gastroenterol 2013; 19(47): 8880-8886
Url http://www.wjgnet.com/1007-9327/full/v19/i47/8880.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i47.8880
Full Article (PDF) WJG-19-8880.pdf
Manuscript File 5228-Review.docx
Answering Reviewers 5228-Answering reviewers.pdf
Copyright License Agreement 5228-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 5228-Language certificate.pdf
Peer-review Report 5228-Peer review(s).pdf
Scientific Editor Work List 5228-Scientific editor work list.doc