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5/21/2020 12:02:13 PM | Browse: 18 | Download: 42
Publication Name World Journal of Gastroenterology
Manuscript ID 52491
Country/Territory China
Received
2019-11-28 14:18
Peer-Review Started
2019-11-28 14:20
To Make the First Decision
Return for Revision
2020-01-19 19:18
Revised
2020-02-20 15:45
Second Decision
2020-04-17 08:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-17 18:04
Articles in Press
2020-04-17 18:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-04-21 10:50
Typeset the Manuscript
2020-05-20 01:59
Publish the Manuscript Online
2020-05-21 12:02
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Biochemistry and Molecular Biology
Manuscript Type Basic Study
Article Title MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer
Manuscript Source Unsolicited Manuscript
All Author List Kun-Dong Zhang, Bin Hu, Gang Cen, Yu-Han Yang, Wei-Wei Chen, Zeng-Ya Guo, Xiao-Feng Wang, Qian Zhao and Zheng-Jun Qiu
ORCID
Author(s) ORCID Number
Kun-Dong Zhang http://orcid.org/0000-0002-2232-2153
Bin Hu http://orcid.org/0000-0002-6441-8487
Gang Cen http://orcid.org/0000-0003-1605-4591
Yu-Han Yang http://orcid.org/0000-0002-3717-5088
Wei-Wei Chen http://orcid.org/0000-0001-8325-5663
Zeng-Ya Guo http://orcid.org/0000-0001-8310-5147
Xiao-Feng Wang http://orcid.org/0000-0002-3067-8985
Qian Zhao http://orcid.org/0000-0002-1827-9789
Zheng-Jun Qiu http://orcid.org/0000-0002-8318-847X
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81372640
Corresponding author Zheng-Jun Qiu, MD, PhD, Chief Doctor, Professor, Surgeon, Department of General Surgery, Shanghai Key Laboratory of Pancreatic Disease, Shanghai General Hospital, Shanghai Jiaotong University, No. 100 Haining Road, Shanghai 200080, China. qiudoctor@sina.com
Keywords miR-301a; Epithelial-mesenchymal transition; Pancreatic cancer; Hypoxia; HIF-2α; TP63
Core Tip In this study, we found that miR-301a expression was increased during the process of hypoxia-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) cells. MiR-301a overexpression facilitated hypoxia-induced EMT, while miR-301a knockout inhibited hypoxia-induced EMT in PC cells. The increased expression of miR-301a was transcriptionally regulated by HIF-2α. In addition, we identified a new target gene of miR-301a, namely, TP63, and confirmed that TP63 was involved in EMT and metastasis of PC cells. Collectively, our data suggest that the newly identified HIF-2α-miR301a-TP63 signaling pathway play a crucial role in hypoxia-induced EMT in pancreatic ductal adenocarcinoma and that miR-301a may serve as a new prognostic biomarker and candidate miRNA for tumor diagnosis and treatments.
Publish Date 2020-05-21 12:02
Citation Zhang KD, Hu B, Cen G, Yang YH, Chen WW, Guo ZY, Wang XF, Zhao Q, Zheng-Jun Qiu ZJ. MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer. World J Gastroenterol 2020; 26(19): 2349-2373
Url https://www.wjgnet.com/1007-9327/full/v26/i19/2349.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i19.2349
Full Article (PDF) WJG-26-2349.pdf
Full Article (Word) WJG-26-2349.docx
Manuscript File 52491-Review_WangTQ.docx
Answering Reviewers 52491-Answering reviewers.pdf
Audio Core Tip 52491-Audio core tip.m4a
Biostatistics Review Certificate 52491-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52491-Conflict-of-interest statement.pdf
Copyright License Agreement 52491-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52491-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52491-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 52491-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 52491-Language certificate.pdf
Peer-review Report 52491-Peer-review(s).pdf
Scientific Misconduct Check 52491-Scientific misconduct check.pdf
Scientific Editor Work List 52491-Scientific editor work list.pdf