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7/28/2020 2:46:56 PM | Browse: 24 | Download: 15
Publication Name World Journal of Gastroenterology
Manuscript ID 52542
Country/Territory China
Received
2020-01-30 13:49
Peer-Review Started
2020-01-30 13:50
To Make the First Decision
Return for Revision
2020-04-22 23:33
Revised
2020-05-21 13:04
Second Decision
2020-06-24 08:45
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-06-25 04:54
Articles in Press
2020-06-25 04:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-03 02:23
Typeset the Manuscript
2020-07-28 07:32
Publish the Manuscript Online
2020-07-28 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats
Manuscript Source Unsolicited Manuscript
All Author List Wei Su, Yang Tai, Shi-Hang Tang, Yan-Ting Ye, Chong Zhao, Jin-Hang Gao, Bi-Guang Tuo and Cheng-Wei Tang
ORCID
Author(s) ORCID Number
Wei Su http://orcid.org/0000-0002-3422-6425
Yang Tai http://orcid.org/0000-0001-8847-5075
Shi-Hang Tang http://orcid.org/0000-0002-3488-2246
Yan-Ting Ye http://orcid.org/0000-0002-2973-5823
Chong Zhao http://orcid.org/0000-0002-0123-770X
Jin-Hang Gao http://orcid.org/0000-0002-6828-1561
Bi-Guang Tuo http://orcid.org/0000-0003-3147-3487
Cheng-Wei Tang http://orcid.org/0000-0002-2289-8240
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Fund of China U1702281
National Natural Science Fund of China 81670551
National Natural Science Fund of China 81873584
Corresponding author Cheng-Wei Tang, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, West China Hospital, Sichuan University, No. 37, Guo Xue Lane, Chengdu 610041, Sichuan Province, China. shcqcdmed@163.com
Keywords Liver fibrosis; Endoplasmic reticulum stress; Celecoxib; Cyclooxygenase-2; CCAAT/enhancer binding protein homologous protein; Apoptosis
Core Tip This study aims to explore the important role of celecoxib in modulating hepatocyte apoptosis during the development of liver fibrosis; to clarify that the mechanism of its regulation is mediated by endoplasmic reticulum stress, which in turn affects the progress of liver fibrosis. We concluded that therapeutic administration of celecoxib can effectively reduce hepatic apoptosis in thioacetamide-induced cirrhotic rats. The mechanism of action may be attributed to the suppression of CCAAT/enhancer binding protein homologous protein expression, which subsequently inhibited endoplasmic reticulum stress.
Publish Date 2020-07-28 14:46
Citation Su W, Tai Y, Tang SH, Ye YT, Zhao C, Gao JH, Tuo BG, Tang CW. Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats. World J Gastroenterol 2020; 26(28): 4094-4107
Url https://www.wjgnet.com/1007-9327/full/v26/i28/4094.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i28.4094
Full Article (PDF) WJG-26-4094.pdf
Full Article (Word) WJG-26-4094.docx
Manuscript File 52542-Review_WangTQ.doc
Answering Reviewers 52542-Answering reviewers.pdf
Audio Core Tip 52542-Audio core tip.m4a
Biostatistics Review Certificate 52542-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 52542-Conflict-of-interest statement.pdf
Copyright License Agreement 52542-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 52542-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 52542-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 52542-Language certificate.pdf
Peer-review Report 52542-Peer-review(s).pdf
Scientific Misconduct Check 52542-Bing-Yan JP-1.png
Scientific Misconduct Check 52542-Bing-Dou Y-2.png
Scientific Misconduct Check 52542-Scientific misconduct check.pdf
Scientific Editor Work List 52542-Scientific editor work list.pdf