| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Dong-Qin Zhao, Hua Xue and Hai-Ji Sun |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31501861 |
| National Natural Science Foundation of China |
31672286 |
| Natural Science Foundation of Shandong Province, China |
ZR2015CM013 |
|
| Corresponding Author |
Hai-Ji Sun, PhD, Associate Professor, Teacher, Key Laboratory of Animal Resistance of Shandong Province, College of Life Sciences, Shandong Normal University, No. 88, East Wenhua Road, Lixia District, Jinan 250014, Shandong Province, China. 109127@sdnu.edu.cn |
| Key Words |
Restraint water-immersion stress; Stress-induced gastric mucosal lesion; Central mechanism; Peripheral mechanism; Neurotransmitter/neuromodulator; Pathway |
| Core Tip |
The nervous mechanisms of gastric mucosal lesion in rats subjected to restraint water-immersion stress were investigated. Abnormal regulation of enteric nervous system, mainly due to the enhanced activity of parasympathetic nervous system, can induce gastrointestinal dysfunction. The central nucleus such as dorsal motor nucleus of vagus, nucleus ambiguous, nucleus of the solitary tract, paraventricular nucleus, supraoptic nucleus, mediodorsal nucleus of the thalamus, central nucleus of the amygdala and medial prefrontal cortex were all involved in the formation of stress-induced gastric mucosal lesion. Nitric oxide, 5-hydroxytryptamine, hydrogen sulfide, calcitonin gene-related peptide, vasoactive intestinal peptide, acetylcholine, catecholamine, glutamate, γ-aminobutyric acid, oxytocin and arginine vasopressin might be involved in the physiological process. |
| Publish Date |
2020-05-28 13:08 |
| Citation |
Zhao DQ, Xue H, Sun HJ. Nervous mechanisms of restraint water-immersion stress-induced gastric mucosal lesion. World J Gastroenterol 2020; 26(20): 2533-2549 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i20/2533.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i20.2533 |
