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Publication Name World Journal of Psychiatry
Manuscript ID 53545
Country/Territory United States
2019-12-24 14:49
Peer-Review Started
2019-12-24 14:51
To Make the First Decision
Return for Revision
2020-02-20 05:01
2020-03-18 20:46
Second Decision
2020-03-25 07:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-03-26 13:40
Articles in Press
2020-03-26 13:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-05-08 08:56
Publish the Manuscript Online
2020-05-14 10:09
ISSN 2220-3206 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Anesthesiology
Manuscript Type Minireviews
Article Title Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics
Manuscript Source Invited Manuscript
All Author List Anatoly E Martynyuk, Ling-Sha Ju, Timothy E Morey and Jia-Qiang Zhang
Author(s) ORCID Number
Anatoly E Martynyuk http://orcid.org/0000-0002-9915-5584
Ling-Sha Ju http://orcid.org/0000-0001-7266-0794
Timothy E Morey http://orcid.org/0000-0003-2922-8984
Jia-Qiang Zhang http://orcid.org/0000-0002-1367-9644
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health R01NS091542
National Natural Science Foundation of China 81771149
National Natural Science Foundation of China U1704165
Corresponding Author Anatoly E Martynyuk, DSc, PhD, Professor, Department of Anesthesiology and the McKnight Brain Institute, University of Florida College of Medicine, 1600 SW Archer Road, PO Box 100254, Gainesville, FL 32610, United States. amartynyuk@anest.ufl.edu
Key Words Brain; General anesthetic; Sevoflurane; Corticosterone; Cortisol; Histone acetylation
Core Tip The GABAergic general anesthetics may act as stressors and endocrine disruptors in neonates and young adults. They may induce two distinct types of long-term adverse effects: neuroendocrine effects (the somatic effects) and epigenetic reprogramming of germ cells (the germ cell effects). The latter may pass neurobehavioral abnormalities to male offspring. Compared to the somatic cells, the germ cells may be more sensitive to the deleterious effects of general anesthetics, raising the possibility that the offspring may be affected even when levels of anesthesia are not harmful to the exposed parents. Further rigorous experimental testing of all these possibilities is required.
Publish Date 2020-05-14 10:09
Citation Martynyuk AE, Ju LS, Morey TE, Zhang JQ. Neuroendocrine, epigenetic, and intergenerational effects of general anesthetics. World J Psychiatr 2020; 10(5): 81-94
URL https://www.wjgnet.com/2220-3206/full/v10/i5/81.htm
DOI https://dx.doi.org/10.5498/wjp.v10.i5.81
Full Article (PDF) WJP-10-81.pdf
Full Article (Word) WJP-10-81.docx
Manuscript File 53545-Review.docx
Answering Reviewers 53545-Answering reviewers.pdf
Audio Core Tip 53545-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 53545-Conflict-of-interest statement.pdf
Copyright License Agreement 53545-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53545-Grant application form(s).pdf
Peer-review Report 53545-Peer-review(s).pdf
Scientific Misconduct Check 53545-Scientific misconduct check.pdf
Scientific Editor Work List 53545-Scientific editor work list.pdf