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3/24/2020 5:16:35 AM | Browse: 20 | Download: 10
Publication Name World Journal of Hepatology
Manuscript ID 53546
Country/Territory United Kingdom
Received
2019-12-24 07:18
Peer-Review Started
2019-12-23 16:49
To Make the First Decision
2019-12-24 07:35
Return for Revision
2019-12-24 07:35
Revised
2019-12-24 07:52
Second Decision
2020-01-11 10:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-01-15 00:45
Articles in Press
2020-01-15 00:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-03-18 03:30
Publish the Manuscript Online
2020-03-24 05:16
ISSN 1948-5182 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Pathology
Manuscript Type Basic Study
Article Title High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells
Manuscript Source Unsolicited Manuscript
All Author List Reem Ghazali, Kosha J Mehta, SW Annie Bligh, Ihab Tewfik, Dahn Clemens and Vinood B Patel
ORCID
Author(s) ORCID Number
Reem Ghazali http://orcid.org/0000-0003-0971-5275
Kosha J Mehta http://orcid.org/0000-0002-0716-5081
SW Annie Bligh http://orcid.org/0000-0002-4757-2159
Ihab Tewfik http://orcid.org/0000-0001-9760-6532
Dahn Clemens http://orcid.org/0000-0002-2111-5769
Vinood B Patel http://orcid.org/0000-0001-9334-2525
Funding Agency and Grant Number
Corresponding author Vinood B Patel, FRSC, PhD, Reader (Associate Professor), School of Life Sciences, University of Westminster, 115 New Cavendish Street, London W1W 6UW, United Kingdom. v.b.patel@westminster.ac.uk
Keywords Non alcoholic fatty liver disease; Lipogenesis; Omega fatty acids; Mitochondrial dysfunction; Reactive oxygen species; Oxidative stress
Core Tip A high ratio of omega 6:3 fatty acids in the diet has been implicated in the develop-ment of non alcoholic fatty liver disease, a growing epidemic of major concern. The cellular pathology induced by such high ratios remains unknown. Here, we ob-served that in human hepatoma HepG2 (VL-17A) cells, high omega-6:omega-3 ratio reduced mitochondrial activity, increased triglyceride accumulation, elevated reac-tive oxygen species levels and interrupted several mitochondrial functions. Moreo-ver, the increased expression of stearoyl-CoA desaturase, decreased expression of peroxisome proliferator-activated receptor alpha and elevation in cannabinoid recep-tor-1 expression collectively lead to lipogenesis and lipotoxicity, which are key fea-tures of non alcoholic fatty liver disease development.
Publish Date 2020-03-24 05:16
Citation Ghazali R, Mehta KJ, Bligh SA, Tewfik I, Dahn Clemens D, Patel VB. High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells. World J Hepatol 2020; 12(3): 84-98
Url https://www.wjgnet.com/1948-5182/full/v12/i3/84.htm
DOI https://dx.doi.org/10.4254/wjh.v12.i3.84
Full Article (PDF) WJH-12-84.pdf
Full Article (Word) WJH-12-84.docx
Manuscript File 53546-Review.docx
Answering Reviewers 53546-Answering reviewers.pdf
Audio Core Tip 53546-Audio core tip.m4a
Biostatistics Review Certificate 53546-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53546-Conflict-of-interest statement.pdf
Copyright License Agreement 53546-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 53546-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 53546-Institutional review board statement.pdf
Peer-review Report 53546-Peer-review(s).pdf
Scientific Misconduct Check 53546-Scientific misconduct check.pdf
Scientific Editor Work List 53546-Scientific editor work list.pdf