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Publication Name World Journal of Gastroenterology
Manuscript ID 53946
Country/Territory Australia
2020-01-01 02:07
Peer-Review Started
2020-01-01 02:08
To Make the First Decision
Return for Revision
2020-01-19 18:04
2020-03-27 09:40
Second Decision
2020-05-12 08:47
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-12 21:40
Articles in Press
2020-05-12 21:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-05-27 07:35
Publish the Manuscript Online
2020-05-28 13:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus
Manuscript Source Invited Manuscript
All Author List Karen Chiam, George C Mayne, Tingting Wang, David I Watson, Tanya S Irvine, Tim Bright, Lorelle T Smith, Imogen A Ball, Joanne M Bowen, Dorothy M Keefe, Sarah K Thompson and Damian J Hussey
Author(s) ORCID Number
Karen Chiam http://orcid.org/0000-0001-8154-6731
George C Mayne http://orcid.org/0000-0003-2554-586X
Tingting Wang http://orcid.org/0000-0002-7739-4787
David I Watson http://orcid.org/0000-0002-7683-2693
Tanya S Irvine http://orcid.org/0000-0003-0827-0833
Tim Bright http://orcid.org/0000-0003-3700-5262
Lorelle T Smith http://orcid.org/0000-0003-2368-1841
Imogen A Ball http://orcid.org/0000-0002-9629-9064
Joanne M Bowen http://orcid.org/0000-0003-0876-0031
Dorothy M Keefe http://orcid.org/0000-0001-9377-431X
Sarah K Thompson http://orcid.org/0000-0002-9908-6208
Damian J Hussey http://orcid.org/0000-0002-6121-6740
Funding Agency and Grant Number
Funding Agency Grant Number
National Health and Medical Research Council (NHMRC) Project Funding APP1104281
NHMRC Centres of Research Excellence (CRE) Grant APP1040947
Corresponding Author Damian J Hussey, PhD, Senior Scientist, Discipline of Surgery, College of Medicine and Public Health, Flinders University of South Australia, Bedford Park, Adelaide SA 5042, Australia. damian.hussey@flinders.edu.au
Key Words Biomarkers; Exosomes; Extracellular vesicles; Circulating microRNA; MicroRNAs; Plasma
Core Tip Current evidence suggests that circulating small extracellular vesicles (sEVs) function as delivery cargo shuttles for various molecules. MicroRNAs are small non-coding RNAs with important roles in the regulation of gene expression, are often dysregulated in diseases, and are relatively stable in the circulation. MicroRNAs circulating in sEVs are consequently considered as highly suitable candidates for use as non-invasive biomarkers. Extracellular vesicle preparations derived from serum and plasma are recognised to be enriched in sEVs, but not purely comprised of them. Most circulating sEV microRNA biomarker studies have used plasma, but here we show that sEVs isolated from serum are less contaminated with blood cell and protein-associated microRNAs.
Publish Date 2020-05-28 13:08
Citation Chiam K, Mayne GC, Wang T, Watson DI, Irvine TS, Bright T, Smith LT, Ball IA, Bowen JM, Keefe DM, Thompson SK, Hussey DJ. Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus. World J Gastroenterol 2020; 26(20): 2570-2583
Url https://www.wjgnet.com/1007-9327/full/v26/i20/2570.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i20.2570
Full Article (PDF) WJG-26-2570.pdf
Full Article (Word) WJG-26-2570.docx
Manuscript File 53946-Review.docx
Answering Reviewers 53946-Answering reviewers.pdf
Audio Core Tip 53946-Audio core tip.m4a
Biostatistics Review Certificate 53946-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 53946-Conflict-of-interest statement.pdf
Copyright License Agreement 53946-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 53946-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 53946-Institutional review board statement.pdf
Supplementary Material 53946-Supplementary material.pdf
Peer-review Report 53946-Peer-review(s).pdf
Scientific Misconduct Check 53946-Bing-Dou Y-2.png
Scientific Misconduct Check 53946-Scientific misconduct check.pdf
Scientific Editor Work List 53946-Scientific editor work list.pdf