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6/28/2020 10:42:01 AM | Browse: 26 | Download: 13
Publication Name World Journal of Gastroenterology
Manuscript ID 54190
Country/Territory China
Received
2020-03-04 11:38
Peer-Review Started
2020-03-04 11:38
To Make the First Decision
Return for Revision
2020-04-12 17:42
Revised
2020-04-24 15:29
Second Decision
2020-05-29 09:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-29 23:10
Articles in Press
2020-05-29 23:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-06-04 21:56
Typeset the Manuscript
2020-06-27 08:24
Publish the Manuscript Online
2020-06-28 10:42
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Basic Study
Article Title Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology
Manuscript Source Unsolicited Manuscript
All Author List Xiao Meng, Guo-Yi Tang, Cai-Ning Zhao, Qing Liu, Xiao-Yu Xu and Shi-Yu Cao
ORCID
Author(s) ORCID Number
Xiao Meng http://orcid.org/0000-0002-9388-2895
Guo-Yi Tang http://orcid.org/0000-0003-2264-730X
Cai-Ning Zhao http://orcid.org/0000-0002-8045-7371
Qing Liu http://orcid.org/0000-0002-6255-6894
Xiao-Yu Xu http://orcid.org/0000-0001-6216-4260
Shi-Yu Cao http://orcid.org/0000-0002-3405-1645
Funding Agency and Grant Number
Corresponding author Xiao Meng, PhD, Lecturer, Department of Nutrition, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Yuexiu District, Guangzhou 510080, Guangdong Province, China. mengx7@mail2.sysu.edu.cn
Keywords Hovenia dulcis; Alcoholic liver disease; Antioxidant activity; Hepatoprotection; Oxidative stress; Network pharmacology
Core Tip Although some parts of Hovenia dulcis (H. dulcis) provide health impacts, the effects and mechanisms of H. dulcis seeds on alcoholic liver disease (ALD) have not been fully elucidated. In this study, we found that H. dulcis seeds possessed strong antioxidant activity, and contained considerable phenols and flavonoids. H. dulcis seeds attenuated ALD, and improved hepatic antioxidant capacity. Furthermore, results of network pharmacology analyses indicated that kaempferol, stigmasterol and naringenin were the main bioactive compounds in H. dulcis seeds, and that modulating oxidative stress, inflammation, gut-derived products and apoptosis were involved in the mechanisms of H. dulcis seeds’ protective effects on ALD.
Publish Date 2020-06-28 10:42
Citation Meng X, Tang GY, Zhao CN, Liu Q, Xu XY, Cao SY. Hepatoprotective effects of Hovenia dulcis seeds against alcoholic liver injury and related mechanisms investigated via network pharmacology. World J Gastroenterol 2020; 26(24): 3432-3446
Url https://www.wjgnet.com/1007-9327/full/v26/i24/3432.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i24.3432
Full Article (PDF) WJG-26-3432.pdf
Full Article (Word) WJG-26-3432.docx
Manuscript File 54190-Review-Filipodia .docx
Answering Reviewers 54190-Answering reviewers.pdf
Audio Core Tip 54190-Audio core tip.mp3
Biostatistics Review Certificate 54190-Biostatistics statement.PDF
Conflict-of-Interest Disclosure Form 54190-Conflict-of-interest statement.pdf
Copyright License Agreement 54190-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 54190-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 54190-Language certificate.pdf
Supplementary Material 54190-Supplementary material.pdf
Peer-review Report 54190-Peer-review(s).pdf
Scientific Misconduct Check 54190-Scientific misconduct check.pdf
Scientific Editor Work List 54190-Scientific editor work list.pdf