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6/14/2020 1:45:26 PM | Browse: 90 | Download: 114
Publication Name World Journal of Gastroenterology
Manuscript ID 54543
Country/Territory China
Received
2020-02-11 03:11
Peer-Review Started
2020-02-11 03:11
To Make the First Decision
Return for Revision
2020-03-26 23:31
Revised
2020-04-10 02:13
Second Decision
2020-04-24 09:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-24 17:15
Articles in Press
2020-04-24 17:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-08 07:41
Typeset the Manuscript
2020-06-12 08:42
Publish the Manuscript Online
2020-06-14 13:45
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Hsa_circRNA_102610 upregulation in Crohn’s disease promotes transforming growth factor-β1-induced epithelial-mesenchymal transition via sponging of hsa-miR-130a-3p
Manuscript Source Unsolicited Manuscript
All Author List Juan Yin, Yu-Lan Ye, Tong Hu, Li-Juan Xu, Li-Ping Zhang, Ru-Ning Ji, Ping Li, Qian Chen, Jian-Yun Zhu and Zhi Pang
ORCID
Author(s) ORCID Number
Juan Yin http://orcid.org/0000-0003-2750-4201
Yu-Lan Ye http://orcid.org/0000-0001-6378-5675
Tong Hu http://orcid.org/0000-0002-4983-7448
Li-Juan Xu http://orcid.org/0000-0002-4109-6606
Li-Ping Zhang http://orcid.org/0000-0002-8627-8948
Ru-Ning Ji http://orcid.org/0000-0003-4788-0626
Ping Li http://orcid.org/0000-0003-2692-786X
Qian Chen http://orcid.org/0000-0002-3585-305X
Jian-Yun Zhu http://orcid.org/0000-0002-9485-8440
Zhi Pang http://orcid.org/0000-0002-1164-5838
Funding Agency and Grant Number
Funding Agency Grant Number
Suzhou Special Project of Diagnosis and Treatment for Key Clinical Disease LCZX201715
Natural Science Foundation of Jiangsu Province BK20161232
Science and technology development fund of Nanjing medical university NMUB2018215
Corresponding author Zhi Pang, PhD, Chief Doctor, Full Professor, Department of Gastroenterology, The North District of the Affiliated Suzhou Hospital of Nanjing Medical University, 242 Guangji Road, Suzhou 215008, Jiangsu Province, China. pangzhi0273@sina.com
Key Words Hsa_circRNA_102610; Hsa-miR-130a-3p; Epithelial-mesenchymal transition; Crohn’s disease; Mothers against decapentaplegic homolog 4; Transforming growth factor-β1
Core Tip The incidence of inflammatory bowel disease, a chronic intestinal inflammatory disorder that includes Crohn’s disease (CD) and ulcerative colitis is rising. Our previous study revealed that hsa_circRNA_102610 is upregulated in CD patients. However, further investigation is required to explore how hsa_circRNA_102610 participates in the pathogenesis of CD. The results of this study indicate that hsa_circRNA_102610 overexpression in CD patients could accelerate the proliferation and epithelial-mesenchymal transition of intestinal epithelial cells via sponging of hsa-miR-130a-3p. Thus hsa_circRNA_102610 may promote CD progression. Hsa_circRNA_102610 may serve as a potential target for CD therapy and novel drug research. Exogenously delivered hsa-miR-130a-3p could possibly act as a sponge of hsa_circRNA_102610.
Publish Date 2020-06-14 13:45
Citation Yin J, Ye YL, Hu T, Xu LJ, Zhang LP, Ji RN, Li P, Chen Q, Zhu JY, Pang Z. Hsa_circRNA_102610 upregulation in Crohn’s disease promotes TGF-β1-induced epithelial-mesenchymal transition via sponging of hsa-miR-130a-3p. World J Gastroenterol 2020; 26(22): 3034-3055
Url https://www.wjgnet.com/1007-9327/full/v26/i22/3034.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i22.3034
Full Article (PDF) WJG-26-3034.pdf
Full Article (Word) WJG-26-3034.docx
Manuscript File 54543-Review-Webster J.docx
Answering Reviewers 54543-Answering reviewers.pdf
Audio Core Tip 54543-Audio core tip.mp3
Biostatistics Review Certificate 54543-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54543-Conflict-of-interest statement.pdf
Copyright License Agreement 54543-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54543-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 54543-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 54543-Language certificate.pdf
Peer-review Report 54543-Peer-review(s).pdf
Scientific Misconduct Check 54543-CrossCheck.png
Scientific Misconduct Check 54543-Scientific misconduct check.pdf
Scientific Editor Work List 54543-Scientific editor work list.pdf