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6/6/2020 2:43:56 PM | Browse: 106 | Download: 94
Publication Name World Journal of Gastroenterology
Manuscript ID 54758
Country/Territory China
2020-02-17 09:30
Peer-Review Started
2020-02-17 09:31
To Make the First Decision
Return for Revision
2020-03-18 04:19
2020-03-26 11:26
Second Decision
2020-04-26 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-04-26 19:10
Articles in Press
2020-04-26 19:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-14 02:43
Typeset the Manuscript
2020-05-27 08:44
Publish the Manuscript Online
2020-06-06 14:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation
Manuscript Source Unsolicited Manuscript
All Author List Qing-Hong Du, Chu-Jun Zhang, Wei-Hong Li, Yan Mu, Ya Xu, Scott Lowe, Lin Han, Xue Yu, Shu-Yan Wang, Yu Li and Jian Li
Author(s) ORCID Number
Qing-Hong Du http://orcid.org/0000-0002-3753-5995
Chu-Jun Zhang http://orcid.org/0000-0002-3712-5873
Wei-Hong Li http://orcid.org/0000-0003-3562-6532
Yan Mu http://orcid.org/0000-0002-5010-7741
Ya Xu http://orcid.org/0000-0003-0272-9703
Scott Lowe http://orcid.org/0000-0002-1711-5766
Lin Han http://orcid.org/0000-0002-0328-7428
Xue Yu http://orcid.org/0000-0002-7703-0764
Shu-Yan Wang http://orcid.org/0000-0002-7400-7550
Yu Li http://orcid.org/0000-0002-9077-9294
Jian Li http://orcid.org/0000-0002-8864-0621
Funding Agency and Grant Number
Funding Agency Grant Number
Innovation Team of the Beijing University of Chinese Medicine 2019-JYB-TD-006
National Natural Science Foundation of China 81873099
Scientific Research Support Plan for the Construction of Doctoral Program of University of Tibetan Medicine
Corresponding author Jian Li, PhD, Professor, Teacher, Department of histology and embryology, School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 Bei san huan dong Road, Beijing 102488, China. lijian@bucm.edu.cn
Key Words Liver fibrosis; Gan Shen Fu Fang; Inflammatory response; Extracellular signal-regulated kinase phosphorylation; In vivo; In vitro
Core Tip Liver fibrosis is the final result of various kinds of chronic liver disease and there is no specific strategy so far. Inflammatory response and extracellular signal-regulated kinase cascade play an important part in liver fibrosis development and progression. In this study, we observe the effects of herbal medicine, Gan Shen Fu Fang (GSFF) on liver fibrosis in vivo and in vitro. The results indicate that GSFF alleviates liver fibrosis progression in vivo and inhibits HSC-T6 activation in vitro, which may be related with inhibited inflammatory response and downregulated extracellular signal-regulated kinase phosphorylation. GSFF may provide hope for liver fibrosis treatment.
Publish Date 2020-06-06 14:43
Citation Du QH, Zhang CJ, Li WH, Mu Y, Xu Y, Lowe S, Han L, Yu X, Wang SY, Li Y, Li J. Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation. World J Gastroenterol 2020; 26(21): 2810-2820
Url https://www.wjgnet.com/1007-9327/full/v26/i21/2810.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i21.2810
Full Article (PDF) WJG-26-2810.pdf
Full Article (Word) WJG-26-2810.docx
Manuscript File 54758-Review-Ma JY.docx
Answering Reviewers 54758-Answering reviewers.pdf
Audio Core Tip 54758-Audio core tip.mp3
Biostatistics Review Certificate 54758-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 54758-Conflict-of-interest statement.pdf
Copyright License Agreement 54758-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54758-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 54758-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 54758-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 54758-Language certificate.pdf
Peer-review Report 54758-Peer-review(s).pdf
Scientific Misconduct Check 54758-Bing-Tang JZ-2.png
Scientific Misconduct Check 54758-Scientific misconduct check.pdf
Scientific Editor Work List 54758-Scientific editor work list.pdf