ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Qing-Hong Du, Chu-Jun Zhang, Wei-Hong Li, Yan Mu, Ya Xu, Scott Lowe, Lin Han, Xue Yu, Shu-Yan Wang, Yu Li and Jian Li |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Innovation Team of the Beijing University of Chinese Medicine |
2019-JYB-TD-006 |
National Natural Science Foundation of China |
81873099 |
Scientific Research Support Plan for the Construction of Doctoral Program of University of Tibetan Medicine |
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Corresponding Author |
Jian Li, PhD, Professor, Teacher, Department of histology and embryology, School of Traditional Chinese medicine, Beijing University of Chinese Medicine, No. 11 Bei san huan dong Road, Beijing 102488, China. lijian@bucm.edu.cn |
Key Words |
Liver fibrosis; Gan Shen Fu Fang; Inflammatory response; Extracellular signal-regulated kinase phosphorylation; In vivo; In vitro |
Core Tip |
Liver fibrosis is the final result of various kinds of chronic liver disease and there is no specific strategy so far. Inflammatory response and extracellular signal-regulated kinase cascade play an important part in liver fibrosis development and progression. In this study, we observe the effects of herbal medicine, Gan Shen Fu Fang (GSFF) on liver fibrosis in vivo and in vitro. The results indicate that GSFF alleviates liver fibrosis progression in vivo and inhibits HSC-T6 activation in vitro, which may be related with inhibited inflammatory response and downregulated extracellular signal-regulated kinase phosphorylation. GSFF may provide hope for liver fibrosis treatment. |
Publish Date |
2020-06-06 14:43 |
Citation |
Du QH, Zhang CJ, Li WH, Mu Y, Xu Y, Lowe S, Han L, Yu X, Wang SY, Li Y, Li J. Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signal-regulated kinase phosphorylation. World J Gastroenterol 2020; 26(21): 2810-2820 |
URL |
https://www.wjgnet.com/1007-9327/full/v26/i21/2810.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v26.i21.2810 |