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6/25/2020 10:09:17 AM | Browse: 671 | Download: 1057
Publication Name World Journal of Stem Cells
Manuscript ID 54891
Country/Territory China
Received
2020-02-24 13:05
Peer-Review Started
2020-02-24 13:06
To Make the First Decision
Return for Revision
2020-04-25 21:47
Revised
2020-05-09 14:13
Second Decision
2020-05-19 08:20
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-20 06:10
Articles in Press
2020-05-20 06:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-23 12:55
Typeset the Manuscript
2020-06-23 14:55
Publish the Manuscript Online
2020-06-25 10:09
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Energy metabolism in cancer stem cells
Manuscript Source Invited Manuscript
All Author List Xuan Zhu, Hui-Hui Chen, Chen-Yi Gao, Xin-Xin Zhang, Jing-Xin Jiang, Yi Zhang, Jun Fang, Feng Zhao and Zhi-Gang Chen
ORCID
Author(s) ORCID Number
Xuan Zhu http://orcid.org/0000-0003-1603-2536
Hui-Hui Chen http://orcid.org/0000-0002-3905-7907
Chen-Yi Gao http://orcid.org/0000-0001-7719-5115
Xin-Xin Zhang http://orcid.org/0000-0002-5948-1705
Jing-Xin Jiang http://orcid.org/0000-0001-7415-158X
Yi Zhang http://orcid.org/0000-0002-8911-6338
Jun Fang http://orcid.org/0000-0001-8381-1893
Feng Zhao http://orcid.org/0000-0002-7257-4279
Zhi-Gang Chen http://orcid.org/0000-0001-8903-7042
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81502564
National Natural Science Foundation of China 81972598
Natural Science Foundation of Zhejiang Province LY19H160004
Corresponding Author Zhi-Gang Chen, MD, PhD, Assistant Professor, Surgeon, Department of Breast Surgery, Zhejiang University School of Medicine, 88 Zheda Road, Hangzhou 310000, Zhejiang Province, China. chenzhigang@zju.edu.cn
Key Words Cancer stem cells; Differentiated cancer cells; Metabolic characteristics; Oxidative phosphorylation; Glycolysis; Tumor microenvironment
Core Tip Accumulating evidence indicates that the inadequacy of many treatments is due to their failure to target cancer stem cells (CSCs). Therefore, CSCs are a promising target for cancer treatment. Recently, it has been reported that CSCs exhibit a unique metabolic phenotype compared to normal cancer cells (non-CSCs), and CSCs can dynamically transform their metabolic state to favor glycolysis or oxidative metabolism. However, the mechanism of the metabolic plasticity of CSCs has not been fully elucidated, and existing evidence indicates that the metabolic phenotype of cancer cells is closely related to the tumor microenvironment (TME). In this article we summarized the metabolic characteristics of non-CSCs and CSCs, highlighted the mechanisms by which CSCs alter their energy metabolism via interactions with the surrounding TME, and discussed the potential therapeutic strategies to target energy metabolism in CSCs.
Publish Date 2020-06-25 10:09
Citation Zhu X, Chen HH, Gao CY, Zhang XX, Jiang JX, Zhang Y, Fang J, Zhao F, Chen ZG. Energy metabolism in cancer stem cells. World J Stem Cells 2020; 12(6): 448-461
URL https://www.wjgnet.com/1948-0210/full/v12/i6/448.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i6.448
Full Article (PDF) WJSC-12-448.pdf
Full Article (Word) WJSC-12-448.docx
Manuscript File 54891-Review_WangTQ.docx
Answering Reviewers 54891-Answering reviewers.pdf
Audio Core Tip 54891-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 54891-Conflict-of-interest statement.pdf
Copyright License Agreement 54891-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 54891-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 54891-Language certificate.pdf
Peer-review Report 54891-Peer-review(s).pdf
Scientific Misconduct Check 54891-Bing-Yu XQ-1.png
Scientific Misconduct Check 54891-Scientific misconduct check.pdf
Scientific Editor Work List 54891-Scientific editor work list.pdf