| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Review |
| Article Title |
Human hair follicle-derived mesenchymal stem cells: Isolation, expansion, and differentiation
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Bo Wang, Xiao-Mei Liu, Zi-Nan Liu, Yuan Wang, Xing Han, Ao-Bo Lian, Ying Mu, Ming-Hua Jin and Jin-Yu Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81573067 |
| Joint Construction Project between Jilin Province and Provincial Colleges |
SXGJQY2017-12 |
| Jilin Province Science and Technology Development Plan |
20190304044YY |
| Innovative Special Industry Fund Project in Jilin Province |
2018C049-2 |
| Open Research Project of the State Key Laboratory of Industrial Control Technology, Zhejiang University, China |
ICT1800381 |
|
| Corresponding Author |
Jin-Yu Liu, PhD, Dean, Professor, Department of Toxicology, School of Public Health, Jilin University, 1163 Xinmin Avenue, Changchun 130021, Jilin Province, China. 610950173@qq.com |
| Key Words |
Human hair follicle; Regenerative therapy; Mesenchymal stem cell; Tissue engineering; Cell differentiation; |
| Core Tip |
In this review, we describe the applications of human hair follicle-derived mesenchymal stem cells (hHF-MSCs) in tissue engineering and regenerative medicine. We have described protocols for isolating hHF-MSCs from human hair follicles and their culture condition in detail. We also summarize strategies for maintaining hHF-MSCs in a highly proliferative but undifferentiated state after repeated in vitro passages, including supplement growth factors, 3D suspension culture technology, and 3D aggregates of MSCs. In addition, we report the potential of hHF-MSCs in induced smooth muscle cells and tissue-engineered blood vessels, regenerated hair follicles, induced red blood cells, and induced pluripotent stem cells. |
| Publish Date |
2020-06-25 10:09 |
| Citation |
Wang B, Liu XM, Liu ZN, Wang Y, Han X, Lian AB, Mu Y, Jin MH, Liu JY. Human hair follicle-derived mesenchymal stem cells: Isolation, expansion, and differentiation. World J Stem Cells 2020; 12(6): 462-470 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i6/462.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i6.462 |
