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5/28/2020 1:08:01 PM | Browse: 136 | Download: 192
Publication Name World Journal of Gastroenterology
Manuscript ID 55150
Country/Territory China
2020-03-14 02:23
Peer-Review Started
2020-03-14 02:23
To Make the First Decision
Return for Revision
2020-04-12 03:35
2020-04-13 12:32
Second Decision
2020-05-14 10:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-05-15 01:23
Articles in Press
2020-05-15 01:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-05-18 00:11
Typeset the Manuscript
2020-05-26 05:57
Publish the Manuscript Online
2020-05-28 13:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Basic Study
Article Title Sleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats
Manuscript Source Unsolicited Manuscript
All Author List Rexiati Ruze, Ya-Cheng Xiong, Jian-Wen Li, Ming-Wei Zhong, Qian Xu, Zhi-Bo Yan, Jian-Kang Zhu, Yu-Gang Cheng, San-Yuan Hu and Guang-Yong Zhang
Author(s) ORCID Number
Rexiati Ruze http://orcid.org/0000-0002-0891-5307
Ya-Cheng Xiong http://orcid.org/0000-0002-9642-5737
Jian-Wen Li http://orcid.org/0000-0003-2035-8838
Ming-Wei Zhong http://orcid.org/0000-0002-6548-550X
Qian Xu http://orcid.org/0000-0002-6174-3348
Zhi-Bo Yan http://orcid.org/0000-0003-3065-0621
Jian-Kang Zhu http://orcid.org/0000-0001-5007-9528
Yu-Gang Cheng http://orcid.org/0000-0003-3600-7047
San-Yuan Hu http://orcid.org/0000-0002-0885-4292
Guang-Yong Zhang http://orcid.org/0000-0001-5308-0129
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81370496
National Natural Science Foundation of China 81873647
Youth Program of National Natural Science Foundation of China 81600059
Corresponding author Guang-Yong Zhang, DSc, MD, PhD, Chief Doctor, Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University, No. 16766, Jingshi Road, Jinan 250014, Shandong Province, China. guangyongzhang@hotmail.com
Key Words Sleeve gastrectomy; Lung cancer; Endothelin-1 axis; Endothelial dysfunction; DNA damage; Obesity
Core Tip To explore the potential mechanism of bariatric surgery declining the risk of cancer, sleeve gastrectomy (SG) was performed on obese and diabetic rats. As a result, with a disrupted endothelin-1 axis, sham-operated subjects manifested a deteriorated endothelial function and increased risk of developing cancer compared to the healthy controls. However, far more than improving glycometabolism, SG reversed these negative effects by normalizing the endothelin-1 axis and reducing DNA damage, which contributed to the effects of SG ameliorating endothelial function and preventing lung cancer.
Publish Date 2020-05-28 13:08
Citation Ruze R, Xiong YC, Li JW, Zhong MW, Xu Q, Yan ZB, Zhu JK, Cheng YG, Hu SY, Zhang GY. Sleeve gastrectomy ameliorates endothelial function and prevents lung cancer by normalizing endothelin-1 axis in obese and diabetic rats. World J Gastroenterol 2020; 26(20): 2599-2617
Url https://www.wjgnet.com/1007-9327/full/v26/i20/2599.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i20.2599
Full Article (PDF) WJG-26-2599.pdf
Full Article (Word) WJG-26-2599.docx
Manuscript File 55150-Review_WangTQ.docx
Answering Reviewers 55150-Answering reviewers.pdf
Audio Core Tip 55150-Audio core tip.mp3
Biostatistics Review Certificate 55150-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 55150-Conflict-of-interest statement.pdf
Copyright License Agreement 55150-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 55150-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 55150-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 55150-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 55150-Language certificate.pdf
Peer-review Report 55150-Peer-review(s).pdf
Scientific Misconduct Check 55150-CrossCheck.png
Scientific Misconduct Check 55150-Bing-Dou Y-2.png
Scientific Misconduct Check 55150-Scientific misconduct check.pdf
Scientific Editor Work List 55150-Scientific editor work list.pdf