ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Study |
Article Title |
High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Chao Zhou, Ning Zhang, Ting-Ting He, Yao Wang, Li-Fu Wang, Yong-Qiang Sun, Jing Jing, Jing-Jing Zhang, Shuang-Nan Fu, Xuan Wang, Xiao-Xiao Liang, Xin Li, Man Gong and Jun Li |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Thirteen Five-year Great Science and Technology Project |
2018ZX10725506-002 |
National Twelve Five-year Great Science and Technology Project |
2012ZX10005-005 |
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Corresponding Author |
Man Gong, MD, Associate Professor, Department of Integrative Medicine, 5th Medical Center of Chinese PLA General Hospital, No. 100, the 4th Ring Road, Beijing 100039, China. gongman302@163.com |
Key Words |
Hepatitis B virus; Liver failure; Prognosis; Interleukin 6; /; / |
Core Tip |
To triage and prognosticate the outcome is vital for management of patients with hepatitis B virus-associated acute-on-chronic liver failure (HBV-ACLF). Interleukin 6 (IL-6) is related with physiology and pathology of the liver. We found a high level of serum IL-6 was an independent risk factor for mortality in patients with HBV-ACLF. HBV-ACLF patients with high level of IL-6 showed high mortality, especially with persistent high level within 4 wk, indicating that IL-6 was an index of prognosis for HBV-ACLF. |
Publish Date |
2020-08-14 12:33 |
Citation |
Zhou C, Zhang N, He TT, Wang Y, Wang LF, Sun YQ, Jing J, Zhang JJ, Fu SN, Wang X, Liang XX, Li X, Gong M, Li J. High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure. World J Gastroenterol 2020; 26(30): 4479-4488 |
URL |
https://www.wjgnet.com/1007-9327/full/v26/i30/4479.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v26.i30.4479 |