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9/22/2020 6:23:06 AM | Browse: 118 | Download: 215
Publication Name World Journal of Stem Cells
Manuscript ID 56051
Country/Territory Serbia
2020-04-14 19:29
Peer-Review Started
2020-04-14 19:29
To Make the First Decision
Return for Revision
2020-04-29 21:50
2020-05-13 17:29
Second Decision
2020-09-02 12:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-09-02 18:20
Articles in Press
2020-09-02 18:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-09-18 17:12
Publish the Manuscript Online
2020-09-22 06:23
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research and Experimental
Manuscript Type Review
Article Title Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators
Manuscript Source Invited Manuscript
All Author List Aleksandra Jauković, Tamara Kukolj, Hristina Obradović, Ivana Okić-Đorđević, Slavko Mojsilović and Diana Bugarski
Author(s) ORCID Number
Aleksandra Jauković http://orcid.org/0000-0003-2686-7481
Tamara Kukolj http://orcid.org/0000-0002- 3174-4358
Hristina Obradović http://orcid.org/0000-0003-4626-7184
Ivana Okić-Đorđević http://orcid.org/0000-0003-3552-1546
Slavko Mojsilović http://orcid.org/0000-0002-4399-6720
Diana Bugarski http://orcid.org/0000-0002-2629-5471
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Science and Technological Development 451-03-68/2020-14/200015
Corresponding Author Aleksandra Jauković, PhD, Associate Professor, Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr. Subotića 4, PO BOX 102, Belgrade 11129, Serbia. aleksandra@imi.bg.ac.rs
Key Words Mesenchymal stem cells; Pro-inflammatory cytokines; Alarmins; Priming; Boosting therapeutic potential;
Core Tip The inflammatory niche plays a key role in triggering the reparative and immunomodulatory functions of mesenchymal stromal/stem cells (MSCs). This paper summarizes the data on how soluble factors in the inflammatory microenvironment, including pro-inflammatory cytokines secreted by immune cells and alarmins released by damaged cells, affect MSCs’ ability to regenerate tissue and modulate the inflammatory response. We also analyze data from in vitro and in vivo studies, which highlight the influence of these factors on the therapeutic potential of MSCs, thus providing an important background for the development of preconditioning strategies that might improve the outcomes of MSC-based cell therapies.
Publish Date 2020-09-22 06:23
Citation Jauković A, Kukolj T, Obradović H, Okić-Đorđević I, Mojsilović S, Bugarski D. Inflammatory niche: Mesenchymal stromal cell priming by soluble mediators. World J Stem Cells 2020; 12(9): 922-937
URL https://www.wjgnet.com/1948-0210/full/v12/i9/922.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i9.922
Full Article (PDF) WJSC-12-922.pdf
Full Article (Word) WJSC-12-922.docx
Manuscript File 56051-Review.docx
Answering Reviewers 56051-Answering reviewers.pdf
Audio Core Tip 56051-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 56051-Conflict-of-interest statement.pdf
Copyright License Agreement 56051-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56051-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 56051-Language certificate.pdf
Peer-review Report 56051-Peer-review(s).pdf
Scientific Misconduct Check 56051-Bing-Wang JL-1.jpg
Scientific Misconduct Check 56051-Bing-Liu M-2.PNG
Scientific Misconduct Check 56051-Scientific misconduct check.pdf
Scientific Editor Work List 56051-Scientific editor work list.pdf