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7/28/2020 2:46:56 PM | Browse: 25 | Download: 11
Publication Name World Journal of Gastroenterology
Manuscript ID 56238
Country/Territory United States
Received
2020-04-21 19:29
Peer-Review Started
2020-04-21 19:29
To Make the First Decision
Return for Revision
2020-06-04 03:45
Revised
2020-07-08 20:05
Second Decision
2020-07-15 13:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-16 01:52
Articles in Press
2020-07-16 01:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-07-28 07:23
Publish the Manuscript Online
2020-07-28 14:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations
Manuscript Source Unsolicited Manuscript
All Author List Gabriel Benyomo Mpilla, Philip Agop Philip, Bassel El-Rayes and Asfar Sohail Azmi
ORCID
Author(s) ORCID Number
Gabriel Benyomo Mpilla http://orcid.org/0000-0002-0767-015X
Philip Agop Philip http://orcid.org/0000-0002-6513-3491
Bassel El-Rayes http://orcid.org/0000-0002-2661-5746
Asfar Sohail Azmi http://orcid.org/0000-0003-1178-9505
Funding Agency and Grant Number
Funding Agency Grant Number
NIH R01 CA240607-01A1
SKY Foundation Inc
Corresponding author Asfar Sohail Azmi, PhD, Assistant Professor, Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, 4100 John R, HWCRC 732, Detroit, MI 48201, United States. azmia@karmanos.org
Keywords Pancreatic neuroendocrine tumors; Gastroenteropancreatic neuroendocrine tumors; Management; Limitation; Novel Agents; Emerging targets
Core Tip Pancreatic Neuroendocrine Tumors (PNETs) can cause severe morbidity due to excessive hormones production and overall tumor mass. The majority of approved therapeutic options in PNETs lack objective response suggesting that there is still a void in the understanding of the biology of this neoplasia. With the rising incidence and the underestimated prevalence of PNETs in the United States, it is paramount to discuss the challenges associated with the study and the management of this intractable disease for better patient outcomes. In this paper we elaborate on the comprehensive challenges and discuss novel and emerging therapeutic target in PNETs.
Publish Date 2020-07-28 14:46
Citation Mpilla GB, Philip PA, El-Rayes B, Azmi AS. Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations. World J Gastroenterol 2020; 26(28): 4036-4054
Url https://www.wjgnet.com/1007-9327/full/v26/i28/4036.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i28.4036
Full Article (PDF) WJG-26-4036.pdf
Full Article (Word) WJG-26-4036.docx
Manuscript File 56238-Review.docx
Answering Reviewers 56238-Answering reviewers.pdf
Audio Core Tip 56238-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 56238-Conflict-of-interest statement.pdf
Copyright License Agreement 56238-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 56238-Grant application form(s).pdf
Peer-review Report 56238-Peer-review(s).pdf
Scientific Misconduct Check 56238-Scientific misconduct check.pdf
Scientific Editor Work List 56238-Scientific editor work list.pdf