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9/4/2020 7:25:49 AM | Browse: 191 | Download: 369
Publication Name World Journal of Gastroenterology
Manuscript ID 56442
Country/Territory Italy
2020-04-30 10:34
Peer-Review Started
2020-04-30 10:35
To Make the First Decision
Return for Revision
2020-06-13 02:42
2020-06-24 20:14
Second Decision
2020-08-19 11:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-08-19 18:32
Articles in Press
2020-08-19 18:32
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-08-28 12:00
Publish the Manuscript Online
2020-09-04 07:25
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells
Manuscript Source Invited Manuscript
All Author List Michela Anna Polidoro, Joanna Mikulak, Valentina Cazzetta, Ana Lleo, Domenico Mavilio, Guido Torzilli and Matteo Donadon
Author(s) ORCID Number
Michela Anna Polidoro http://orcid.org/0000-0002-9162-6855
Joanna Mikulak http://orcid.org/0000-0001-8310-9543
Valentina Cazzetta http://orcid.org/0000-0001-7183-2793
Ana Lleo http://orcid.org/0000-0002-0561-7902
Domenico Mavilio http://orcid.org/0000-0001-6147-0952
Guido Torzilli http://orcid.org/0000-0001-5798-5021
Matteo Donadon http://orcid.org/0000-0003-0296-7648
Funding Agency and Grant Number
Corresponding Author Matteo Donadon, MD, PhD, Assistant Professor, Department of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center - IRCCS, via manzoni, 56, Rozzano 20089, Milan, Italy. matteo.donadon@hunimed.eu
Key Words Primary liver cancer; Natural killer cells; Tumor microenvironment; Hepatocellular carcinoma; Intrahepatic cholangiocarcinoma;
Core Tip Natural killer (NK) cells are an important innate immune cell type with high cytotoxic activity, mainly involved in the clearance of virus-infected and tumor cells. Due to their potential anti-tumor activity, NK cells are gaining a deeper attention as a promising strategy for immune-based cancer therapy. Several studies reveal that both in hepatocellular carcinoma and intrahepatic cholangiocarcinoma, NK cells infiltrate within tumors and their high frequency was found to be related with a favorable overall survival in these patients. In this review, the authors summarize the current literature on NK cells and their role in primary liver tumors.
Publish Date 2020-09-04 07:25
Citation Polidoro MA, Mikulak J, Cazzetta V, Lleo A, Mavilio D, Torzilli G, Donadon M. Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells. World J Gastroenterol 2020; 26(33): 4900-4918
URL https://www.wjgnet.com/1007-9327/full/v26/i33/4900.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i33.4900
Full Article (PDF) WJG-26-4900.pdf
Full Article (Word) WJG-26-4900.docx
Manuscript File 56442-Review.docx
Answering Reviewers 56442-Answering reviewers.pdf
Audio Core Tip 56442-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 56442-Conflict-of-interest statement.pdf
Copyright License Agreement 56442-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 56442-Language certificate.pdf
Peer-review Report 56442-Peer-review(s).pdf
Scientific Misconduct Check 56442-Bing-Yan JP-1.png
Scientific Misconduct Check 56442-Bing-Yan JP-2.png
Scientific Misconduct Check 56442-Scientific misconduct check.pdf
Scientific Editor Work List 56442-Scientific editor work list.pdf