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9/22/2020 6:23:06 AM | Browse: 33 | Download: 41
Publication Name World Journal of Stem Cells
Manuscript ID 57148
Country/Territory China
Received
2020-05-27 07:57
Peer-Review Started
2020-05-27 07:58
To Make the First Decision
Return for Revision
2020-06-15 18:32
Revised
2020-06-23 04:45
Second Decision
2020-07-16 12:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-07-19 20:39
Articles in Press
2020-07-19 20:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
2020-07-27 00:20
Typeset the Manuscript
2020-09-08 05:03
Publish the Manuscript Online
2020-09-22 06:23
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Review
Article Title Senescent mesenchymal stem/stromal cells and restoring their cellular functions
Manuscript Source Invited Manuscript
All Author List Qing-Shu Meng, Jing Liu, Lu Wei, Hui-Min Fan, Xiao-Hui Zhou and Xiao-Ting Liang
ORCID
Author(s) ORCID Number
Qing-Shu Meng http://orcid.org/0000-0002-9879-3138
Jing Liu http://orcid.org/0000-0003-2126-0146
Lu Wei http://orcid.org/0000-0002-7976-5203
Hui-Min Fan http://orcid.org/0000-0002-9776-3180
Xiao-Hui Zhou http://orcid.org/0000-0002-2965-6914
Xiao-Ting Liang http://orcid.org/0000-0003-3262-1858
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81500207
National Natural Science Foundation of China 81670458
National Natural Science Foundation of China 81470393
Shanghai Municipal Health and Family Planning Commission ZY(2018‑2020)‑FWTX‑2007
Shanghai Key Medical Discipline for Critical Care Medicine 2017zz02017
National Key Research and Development Program of China 2017YFA0105600
Major Program of Development Fund for Shanghai Zhangjiang National Innovtaion Demonstration Zone <Stem Cell Strategic Biobank and Stem Cell Clinical Technology Transformation Platform> ZJ2018-ZD-004
Science and Technology Commission of Shanghai Municipality 17431906600
Top-level Clinical Discipline Project of Shanghai Pudong PWYgf2018-05
Corresponding Author Xiao-Ting Liang, MD, PhD, Research Fellow, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150, Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Key Words Mesenchymal stem cells; Senescence; Features; Function; Rejuvenation strategy;
Core Tip Mesenchymal stem cells (MSCs) administration is a promising therapeutic strategy for various human diseases. However, cell aging limits MSCs function and therapeutic properties via reducing their activities. We review the morphological changes, molecular expression alterations and functional degeneration of aged MSCs, and the effects of aged MSCs on immune cells and other target cells. Additionally, we summarize the strategies to rejuvenate aged MSCs to enhance their clinical potential.
Publish Date 2020-09-22 06:23
Citation Meng QS, Liu J, Wei L, Fan HM, Zhou XH, Liang XT. Senescent mesenchymal stem/stromal cells and restoring their cellular functions. World J Stem Cells 2020; 12(9): 966-985
Url https://www.wjgnet.com/1948-0210/full/v12/i9/966.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i9.966
Full Article (PDF) WJSC-12-966.pdf
Full Article (Word) WJSC-12-966.docx
Manuscript File 57148-Review_WangTQ.docx
Answering Reviewers 57148-Answering reviewers.pdf
Audio Core Tip 57148-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 57148-Conflict-of-interest statement.pdf
Copyright License Agreement 57148-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 57148-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 57148-Language certificate.pdf
Peer-review Report 57148-Peer-review(s).pdf
Scientific Misconduct Check 57148-Bing-Yan JP-2.png
Scientific Misconduct Check 57148-Scientific misconduct check.pdf
Scientific Editor Work List 57148-Scientific editor work list.pdf