| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Virology |
| Manuscript Type |
Minireviews |
| Article Title |
Regulation of expression of proinflammatory cytokines by SARS-CoV-2
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiang-Ning Zhang, Long-Ji Wu, Xia Kong, Bi-Ying Zheng, Zhe Zhang and Zhi-Wei He |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Medical Scientific Research Foundation of Guangdong Province of China, Guangdong Provincial Health Commission, China |
No. A2018356 |
|
| Corresponding Author |
Xiang-Ning Zhang, MD, PhD, Associate Professor, Department of Pathophysiology, Guangdong Medical University, No. 1 Xincheng Road, Songshan Lake District, Dongguan 523808, Guangdong Province, China. zhangxn_2006@126.com |
| Key Words |
SARS-CoV-2; COVID-19; Proinflammatory cytokines; Transcription factor; Histone; Post-translational modification |
| Core Tip |
An infection by a novel coronavirus originated in Wuhan, China has spread rapidly, causing a global pandemic. Clinically the infection coronavirus disease-19 (COVID-19) is similar with severe acute respiratory syndrome, having fever, cough, and upper airway congestion, along with high production of proinflammatory cytokines (PICs), forming a cytokine storm. PICs induced include interleukin (IL)-6, IL-17, and monocyte chemoattractant protein-1. Their production is regulated by transcription factors, and post-translational modification of histones, which activates or represses gene transcription. PICs in turn stimulate exudation of hyaluronic acid, implicated in pathogenesis of COVID-19. Their role as the therapeutic target is suggested. |
| Publish Date |
2021-03-01 03:51 |
| Citation |
Zhang XN, Wu LJ, Kong X, Zheng BY, Zhang Z, He ZW. Regulation of expression of proinflammatory cytokines by SARS-CoV-2. World J Clin Cases 2021; 9(7): 1513-1523 |
| URL |
https://www.wjgnet.com/2307-8960/full/v9/i7/1513.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v9.i7.1513 |
