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3/1/2021 3:51:07 AM | Browse: 210 | Download: 355
Publication Name World Journal of Clinical Cases
Manuscript ID 59235
Country/Territory China
Received
2020-10-13 13:18
Peer-Review Started
2020-10-13 13:19
To Make the First Decision
Return for Revision
2020-11-26 03:17
Revised
2020-12-08 08:08
Second Decision
2020-12-24 06:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-12-25 04:57
Articles in Press
2020-12-25 04:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-01-27 05:29
Typeset the Manuscript
2021-02-24 06:11
Publish the Manuscript Online
2021-03-01 03:51
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Minireviews
Article Title Regulation of expression of proinflammatory cytokines by SARS-CoV-2
Manuscript Source Invited Manuscript
All Author List Xiang-Ning Zhang, Long-Ji Wu, Xia Kong, Bi-Ying Zheng, Zhe Zhang and Zhi-Wei He
ORCID
Author(s) ORCID Number
Xiang-Ning Zhang http://orcid.org/0000-0002-7875-5548
Long-Ji Wu http://orcid.org/0000-0003-3379-2633
Xia Kong http://orcid.org/0000-0003-4615-9407
Bi-Ying Zheng http://orcid.org/0000-0003-2817-2683
Zhe Zhang http://orcid.org/0000-0001-8816-3194
Zhi-Wei He http://orcid.org/0001-0000-0020-0011
Funding Agency and Grant Number
Funding Agency Grant Number
Medical Scientific Research Foundation of Guangdong Province of China, Guangdong Provincial Health Commission, China No. A2018356
Corresponding Author Xiang-Ning Zhang, MD, PhD, Associate Professor, Department of Pathophysiology, Guangdong Medical University, No. 1 Xincheng Road, Songshan Lake District, Dongguan 523808, Guangdong Province, China. zhangxn_2006@126.com
Key Words SARS-CoV-2; COVID-19; Proinflammatory cytokines; Transcription factor; Histone; Post-translational modification
Core Tip An infection by a novel coronavirus originated in Wuhan, China has spread rapidly, causing a global pandemic. Clinically the infection coronavirus disease-19 (COVID-19) is similar with severe acute respiratory syndrome, having fever, cough, and upper airway congestion, along with high production of proinflammatory cytokines (PICs), forming a cytokine storm. PICs induced include interleukin (IL)-6, IL-17, and monocyte chemoattractant protein-1. Their production is regulated by transcription factors, and post-translational modification of histones, which activates or represses gene transcription. PICs in turn stimulate exudation of hyaluronic acid, implicated in pathogenesis of COVID-19.  Their role as the therapeutic target is suggested.
Publish Date 2021-03-01 03:51
Citation Zhang XN, Wu LJ, Kong X, Zheng BY, Zhang Z, He ZW. Regulation of expression of proinflammatory cytokines by SARS-CoV-2. World J Clin Cases 2021; 9(7): 1513-1523
URL https://www.wjgnet.com/2307-8960/full/v9/i7/1513.htm
DOI https://dx.doi.org/10.12998/wjcc.v9.i7.1513
Full Article (PDF) WJCC-9-1513.pdf
Full Article (Word) WJCC-9-1513.docx
Manuscript File 59235_Auto_Edited--Webster J-Clear.docx
Answering Reviewers 59235-Answering reviewers.pdf
Audio Core Tip 59235-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 59235-Conflict-of-interest statement.pdf
Copyright License Agreement 59235-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59235-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 59235-Language certificate.pdf
Peer-review Report 59235-Peer-review(s).pdf
Scientific Misconduct Check 59235-Bing-Fan JR-2.png
Scientific Misconduct Check 59235-Bing Ma YJ-1.jpg
Scientific Misconduct Check 59235-Scientific misconduct check.pdf
Scientific Editor Work List 59235-Scientific editor work list.pdf