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Publication Name World Journal of Gastroenterology
Manuscript ID 59539
Country/Territory Japan
2020-09-25 00:06
Peer-Review Started
2020-09-23 05:41
To Make the First Decision
Return for Revision
2020-11-08 16:38
2020-11-11 04:20
Second Decision
2020-12-17 12:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2020-12-23 05:18
Articles in Press
2020-12-23 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-01-06 13:37
Publish the Manuscript Online
2021-01-11 13:20
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Case Control Study
Article Title Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis
Manuscript Source Unsolicited Manuscript
All Author List Kei Motooka, Koichi Morishita, Nami Ito, Shinichiro Shinzaki, Taku Tashiro, Satoshi Nojima, Kayoko Shimizu, Mutsuhiro Date, Natsumi Sakata, Momoko Yamada, Shinji Takamatsu, Yoshihiro Kamada, Hideki Iijima, Tsunekazu Mizushima, Eiichi Morii, Tetsuo Takehara and Eiji Miyoshi
Author(s) ORCID Number
Kei Motooka http://orcid.org/0000-0002-9799-2020
Koichi Morishita http://orcid.org/0000-0002-9350-5504
Nami Ito http://orcid.org/0000-0001-5132-6260
Shinichiro Shinzaki http://orcid.org/0000-0002-7051-618X
Taku Tashiro http://orcid.org/0000-0002-7801-8230
Satoshi Nojima http://orcid.org/0000-0002-9305-8409
Kayoko Shimizu http://orcid.org/0000-0003-0470-6468
Mutsuhiro Date http://orcid.org/0000-0002-3336-1764
Natsumi Sakata http://orcid.org/0000-0002-8761-0172
Momoko Yamada http://orcid.org/0000-0002-6473-5810
Shinji Takamatsu http://orcid.org/0000-0003-1996-7740
Yoshihiro Kamada http://orcid.org/0000-0001-5485-902X
Hideki Iijima http://orcid.org/0000-0002-5423-3059
Tsunekazu Mizushima http://orcid.org/0000-0002-0825-6823
Eiichi Morii http://orcid.org/0000-0001-8490-3650
Tetsuo Takehara http://orcid.org/0000-0001-5036-3457
Eiji Miyoshi http://orcid.org/0000-0002-9430-2362
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Education, Culture, Sports, Science and Technology of Japan 19H03562
FUJIFILM Wako Pure Chemical Corporation J770701626
Corresponding Author Eiji Miyoshi, MD, PhD, Professor, Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, 1-7 Yamada-oka, Suita 565-0871, Osaka, Japan. emiyoshi@sahs.med.osaka-u.ac.jp
Key Words Inflammatory bowel disease; Biomarkers; Glycosylation; Fucosylated haptoglobin; Prohaptoglobin; Endoscopic remission
Core Tip Fucosylation is one of the most important glycosylation involved in cancer and inflammation. Recently, we have succeeded to establish a novel glycan antibody 10-7G mAb which directly recognizes fucosylated haptoglobin (Fuc-Hpt), and developed its enzyme-linked immunosorbent assay (ELISA) system. In this study, we demonstrated the serum 10-7G values (Fuc-Hpt levels determined with 10-7G mAb ELISA) were significantly higher in patients with inflammatory bowel disease. We also found that Fuc-Hpt was produced by lymphocytes infiltrating into inflammatory sites of intestine. Moreover, statistical analyses showed that the 10-7G value could evaluate intestinal inflammation and endoscopic mucosal healing in ulcerative colitis.
Publish Date 2021-01-11 13:20
Citation Motooka K, Morishita K, Ito N, Shinzaki S, Tashiro T, Nojima S, Shimizu K, Date M, Sakata N, Yamada M, Takamatsu S, Kamada Y, Iijima H, Mizushima T, Morii E, Takehara T, Miyoshi E. Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis. World J Gastroenterol 2021; 27(2): 162-175
Url https://www.wjgnet.com/1007-9327/full/v27/i2/162.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i2.162
Full Article (PDF) WJG-27-162.pdf
Full Article (Word) WJG-27-162.docx
Manuscript File 59539_Auto_Edited.docx
Answering Reviewers 59539-Answering reviewers.pdf
Audio Core Tip 59539-Audio core tip.m4a
Biostatistics Review Certificate 59539-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 59539-Conflict-of-interest statement.pdf
Copyright License Agreement 59539-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 59539-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 59539-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 59539-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 59539-Language certificate.pdf
Supplementary Material 59539-Supplementary material.pdf
Peer-review Report 59539-Peer-review(s).pdf
Scientific Misconduct Check 59539-Bing-Yan JP-1.png
Scientific Misconduct Check 59539-Scientific misconduct check.pdf
Scientific Editor Work List 59539-Scientific editor work list.pdf