Publication Name	World Journal of Hepatology
Manuscript ID	59622
Country	Mexico

Received	2020-10-02 19:31
Peer-Review Started	2020-10-02 19:31
To Make the First Decision
Return for Revision	2020-12-03 18:15
Revised	2020-12-14 19:17
Second Decision	2020-12-28 13:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2020-12-28 18:24
Articles in Press	2020-12-28 18:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-01-16 20:56
Typeset the Manuscript	2021-02-01 04:49
Publish the Manuscript Online	2021-02-25 15:45

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical and Translational Research
Article Title	Production and activity of metalloproteinases during liver fibrosis progression of chronic hepatitis C patients
Manuscript Source	Unsolicited Manuscript
All Author List	Moises Martinez-Castillo, Abigail Hernandez-Barragan, Ivonne Flores-Vazconcelos, Marina Galicia-Moreno, Dorothy Rosique-Oramas, Jose Luis Perez-Hernandez, Fatima Higuera-De la Tijera, Eduardo E Montalvo-Jave, Aldo Torre-Delgadillo, Paula Cordero-Perez, Linda Muñoz-Espinosa, David Kershenobich and Gabriela Gutierrez-Reyes
ORCID	Author(s) ORCID Number Moises Martinez-Castillo http://orcid.org/0000-0003-1735-502X Abigail Hernandez-Barragan http://orcid.org/0000-0003-4725-0536 Ivonne Flores-Vazconcelos http://orcid.org/0000-0002-2906-3983 Marina Galicia-Moreno http://orcid.org/0000-0002-7435-1861 Dorothy Rosique-Oramas http://orcid.org/0000-0002-6255-1516 Jose Luis Perez-Hernandez http://orcid.org/0000-0003-4367-8463 Fatima Higuera-De la Tijera http://orcid.org/0000-0003-1862-7541 Eduardo E Montalvo-Jave http://orcid.org/0000-0003-4616-1275 Aldo Torre-Delgadillo http://orcid.org/0000-0002-9299-3075 Paula Cordero-Perez http://orcid.org/0000-0001-7747-8895 Linda Muñoz-Espinosa http://orcid.org/0000-0002-0455-9325 David Kershenobich http://orcid.org/0000-0001-6178-9170 Gabriela Gutierrez-Reyes http://orcid.org/0000-0003-1961-9885
Funding Agency and Grant Number	Funding Agency Grant Number National Council for Science and Technology SALUD-2016-272579 and PAPIIT-UNAM TA200515
Corresponding Author	Gabriela Gutierrez-Reyes, PhD, Academic Research, Professor, Research Scientist, Liver, Pancreas and Motility LaboratoryLiver, Pancreas and Motility Laboratory, Unit of Experimental Medicine, School of Medicine, General Hospital of Mexico, Universidad Nacional Autonoma de Mexico, Dr. Balmis 148 Col Doctores Cuauhtemoc, Mexico City 06726, Mexico. gabgurey@yahoo.com.mx
Key Words	Extracellular matrix; Metalloproteinases; Liver fibrosis; Chronic hepatitis C; Fibrogenesis; Fibrolityc
Core Tip	The relevance of this prospective study was to evaluate the role of metalloproteinases (MMPs) in the pathophysiology of liver fibrosis in chronic hepatitis C patients. MMPs could be used as possible therapeutic targets and as a monitoring tool in treatment-experienced patients that continue to present with liver fibrosis and develop cirrhosis and/or hepatocellular carcinoma.
Publish Date	2021-02-25 15:45
Citation	Martinez-Castillo M, Hernandez-Barragan A, Flores-Vasconcelos I, Galicia-Moreno M, Rosique-Oramas D, Perez-Hernandez JL, Higuera-De la Tijera F, Montalvo-Jave EE, Torre-Delgadillo A, Cordero-Perez P, Muñoz-Espinosa L, Kershenobich D, Gutierrez-Reyes G. Production and activity of metalloproteinases during liver fibrosis progression of chronic hepatitis C patients. World J Hepatol 2021; 13(2): 218-232
URL	https://www.wjgnet.com/1948-5182/full/v13/i2/218.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i2.218

Full Article (PDF)	WJH-13-218.pdf
Full Article (Word)	WJH-13-218.docx
Manuscript File	59622-Review-FilipodiaCL.docx
Answering Reviewers	59622-Answering reviewers.pdf
Audio Core Tip	59622-Audio core tip.m4a
Biostatistics Review Certificate	59622-Biostatistics statement.pdf
Clinical Trial Registration Statement	59622-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	59622-Conflict-of-interest statement.pdf
Copyright License Agreement	59622-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	59622-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	59622-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	59622-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	59622-Language certificate.pdf
Supplementary Material	59622-Supplementary material.pdf
Peer-review Report	59622-Peer-review(s).pdf
Scientific Misconduct Check	59622-Scientific misconduct check.pdf
Scientific Editor Work List	59622-Scientific editor work list.pdf