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9/11/2014 8:39:00 PM | Browse: 528 | Download: 324
Publication Name World Journal of Gastroenterology
Manuscript ID 6063
Country/Territory Argentina
Received
2013-10-01 18:00
Peer-Review Started
2013-10-01 20:03
To Make the First Decision
2013-10-22 16:18
Return for Revision
2013-10-23 19:31
Revised
2013-11-02 01:14
Second Decision
2013-11-18 20:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-11-19 12:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-12-16 11:54
Publish the Manuscript Online
2014-01-20 16:41
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Topic Highlights
Article Title Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma
Manuscript Source Invited Manuscript
All Author List María L Bacigalupo, Malena Manzi, Gabriel A Rabinovich and María F Troncoso
Funding Agency and Grant Number
Corresponding Author María Fernanda Troncoso, PhD, Institute of Biological Chemistry and Biophysics “Prof. Alejandro C. Paladini” (UBA-CONICET), Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, C1113AAD Buenos Aires, Argentina. ma.f.troncoso@gmail.com
Key Words Galectins; Hepatocellular carcinoma; Inflammation-associated liver injury; Hepatitis B or C virus infection-associated hepatocellular carcinoma; Fibrosis-related liver pathologies
Core Tip Galectins, a family of glycan-binding proteins, are involved in the pathogenesis of hepatocellular carcinoma (HCC). Up-regulation of galectin-1, galectin-3 and galectin-4 is observed in HCC cells, whereas galectin-8 and galectin-9 appear to be down-regulated in tumor hepatocytes. This altered expression correlates with tumor growth, HCC cell migration and invasion, tumor aggressiveness, metastasis, postoperative recurrence and poor prognosis. These galectins are also implicated in inflammation- and fibrosis-related liver pathologies.
Publish Date 2014-01-20 16:41
Citation Bacigalupo ML, Manzi M, Rabinovich GA, Troncoso MF. Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma. World J Gastroenterol 2013; 19(47): 8831-8849
URL http://www.wjgnet.com/1007-9327/full/v19/i47/8831.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i47.8831
Full Article (PDF) WJG-19-8831.pdf
Manuscript File 6063-Review.docx
Answering Reviewers 6063-Answering reviewers.pdf
Copyright License Agreement 6063-Copyright assignment.pdf
Peer-review Report 6063-Peer review(s).pdf
Scientific Editor Work List 6063-Scientific editor work list.doc