Publication Name	World Journal of Gastroenterology
Manuscript ID	6063
Country	Argentina

Received	2013-10-01 18:00
Peer-Review Started	2013-10-01 20:03
To Make the First Decision	2013-10-22 16:18
Return for Revision	2013-10-23 19:31
Revised	2013-11-02 01:14
Second Decision	2013-11-18 20:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-11-19 12:06
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-16 11:54
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	María L Bacigalupo, Malena Manzi, Gabriel A Rabinovich and María F Troncoso
Funding Agency and Grant Number
Corresponding Author	María Fernanda Troncoso, PhD, Institute of Biological Chemistry and Biophysics “Prof. Alejandro C. Paladini” (UBA-CONICET), Department of Biological Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, C1113AAD Buenos Aires, Argentina. ma.f.troncoso@gmail.com
Key Words	Galectins; Hepatocellular carcinoma; Inflammation-associated liver injury; Hepatitis B or C virus infection-associated hepatocellular carcinoma; Fibrosis-related liver pathologies
Core Tip	Galectins, a family of glycan-binding proteins, are involved in the pathogenesis of hepatocellular carcinoma (HCC). Up-regulation of galectin-1, galectin-3 and galectin-4 is observed in HCC cells, whereas galectin-8 and galectin-9 appear to be down-regulated in tumor hepatocytes. This altered expression correlates with tumor growth, HCC cell migration and invasion, tumor aggressiveness, metastasis, postoperative recurrence and poor prognosis. These galectins are also implicated in inflammation- and fibrosis-related liver pathologies.
Publish Date	2014-01-20 16:41
Citation	Bacigalupo ML, Manzi M, Rabinovich GA, Troncoso MF. Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma. World J Gastroenterol 2013; 19(47): 8831-8849
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/8831.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.8831

Full Article (PDF)	WJG-19-8831.pdf
Manuscript File	6063-Review.docx
Answering Reviewers	6063-Answering reviewers.pdf
Copyright License Agreement	6063-Copyright assignment.pdf
Peer-review Report	6063-Peer review(s).pdf
Scientific Editor Work List	6063-Scientific editor work list.doc