Publication Name	World Journal of Gastroenterology
Manuscript ID	60924
Country	China

Received	2020-11-20 03:30
Peer-Review Started	2020-11-20 03:30
To Make the First Decision
Return for Revision	2020-12-17 22:45
Revised	2021-01-29 08:16
Second Decision	2021-03-24 12:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-03-25 03:54
Articles in Press	2021-03-25 03:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-04-01 21:19
Typeset the Manuscript	2021-04-14 00:00
Publish the Manuscript Online	2021-04-21 05:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric-ligation-induced gastroduodenal ulcer in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Shan Tong, Huan Wang, Li-Sha A, Ta-Na Bai, Ju-Hua Gong, Wen-Jie Jin, Li-Li Dai, Gen-Na Ba, Sung-Bo Cho and Ming-Hai Fu
ORCID	Author(s) ORCID Number Shan Tong http://orcid.org/0000-0002-6145-0721 Huan Wang http://orcid.org/000-0002-5457-665X Li-Sha A http://orcid.org/0000-0002-0137-1677 Ta-Na Bai http://orcid.org/0000-0002-3590-4355 Ju-Hua Gong http://orcid.org/0000-0001-6433-4518 Wen-Jie Jin http://orcid.org/0000-0002-9288-8697 Li-Li Dai http://orcid.org/0000-0003-4821-596X Gen-Na Ba http://orcid.org/0000-0002-0834-3863 Sung-Bo Cho http://orcid.org/0000-0002-2593-2758 Ming-Hai Fu http://orcid.org/0000-0002-5096-8744
Funding Agency and Grant Number	Funding Agency Grant Number “Mongolian Medicine Food and Drug Source Protection and Utilization Innovation Team” Construction Project 190301 National Natural Science Foundation of China 81760765 Inner Mongolia University for Nationalities Doctoral Start-up Grant BS412 Inner Mongolia University for Nationalities Doctoral Start-up Grant BS413 Mongolian Medicine Engineering Technology Research Centre Open Fund Project MDK2017072 Inner Mongolia Autonomous Region Talent Development Fund Project RC201802
Corresponding Author	Ming-Hai Fu, PhD, Associate Professor, School of Mongolian Medicine, Inner Mongolia University for Nationalities, No. 996 Xilamulun Street, Tongliao 028000, Inner Mongolia Autonomous Region, China. mfu@imun.edu.cn
Key Words	Sulongga-4; Peptic ulcer; Pyloric ligation; Microarray analysis; Inflammatory reaction; Retinol metabolism
Core Tip	Sulongga-4 (SL-4) is a classic herbal formula used in Mongolian medical clinics for the treatment of peptic ulcers and gastroenteritis. The present study investigated the protective effects and molecular mechanisms of SL-4 in the pyloric ligation (PL)-induced gastroduodenal ulcers in rats via microarray study. Our results suggest that SL-4 exhibits profound protective effects against PL-induced gastroduodenal ulcers via reducing inflammatory cytokines and elevating gastric acid inhibitory factor expressions. Down-regulation of CYP2b2 and UGT2b1, and up-regulation of A2m and MASP1 are possibly involved in the gastroduodenal ulcer protection mechanism of SL-4.
Publish Date	2021-04-21 05:56
Citation	Tong S, Wang H, A LS, Bai TN, Gong JH, Jin WJ, Dai LL, Ba GN, Cho SB, Fu MH. Protective effect and mechanisms of action of Mongolian medicine Sulongga-4 on pyloric-ligation-induced gastroduodenal ulcer in rats. World J Gastroenterol 2021; 27(16): 1770-1784
URL	https://www.wjgnet.com/1007-9327/full/v27/i16/1770.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i16.1770

Full Article (PDF)	WJG-27-1770.pdf
Full Article (Word)	WJG-27-1770.docx
Manuscript File	60924-Review-FilipodiaCL.docx
Answering Reviewers	60924-Answering reviewers.pdf
Audio Core Tip	60924-Audio core tip.mp3
Biostatistics Review Certificate	60924-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	60924-Conflict-of-interest statement.pdf
Copyright License Agreement	60924-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	60924-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	60924-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	60924-Language certificate.pdf
Peer-review Report	60924-Peer-review(s).pdf
Scientific Misconduct Check	60924-Bing-Wang JL-1.png
Scientific Misconduct Check	60924-Scientific misconduct check.pdf
Scientific Editor Work List	60924-Scientific editor work list.pdf