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9/10/2021 12:09:57 PM | Browse: 31 | Download: 45
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 61264
Country/Territory China
2021-03-04 03:34
Peer-Review Started
2021-03-04 03:34
To Make the First Decision
Return for Revision
2021-04-06 01:36
2021-04-09 15:46
Second Decision
2021-07-05 12:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-05 13:29
Articles in Press
2021-07-05 13:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-07-12 14:43
Typeset the Manuscript
2021-08-30 08:33
Publish the Manuscript Online
2021-09-10 12:09
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Scoparone inhibits pancreatic cancer through the PI3K/Akt signaling pathway
Manuscript Source Unsolicited Manuscript
All Author List Na Li, Fan Yang, Dong-Yan Liu, Jin-Tao Guo, Nan Ge and Si-Yu Sun
Author(s) ORCID Number
Na Li http://orcid.org/0000-0002-9841-2200
Fan Yang http://orcid.org/0000-0002-5032-6450
Dong-Yan Liu http://orcid.org/0000-0002-3902-9316
Jin-Tao Guo http://orcid.org/0000-0001-5722-6359
Nan Ge http://orcid.org/0000-0002-5764-7054
Si-Yu Sun http://orcid.org/0000-0002-7308-0473
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 817706555
Special Project from the Central Government of Liaoning Province 2018107003
Liaoning Province Medical Science and Technology Achievements Transformation Foundation 2018225120
China Postdoctoral Science Foundation 2020M670101ZX
Doctoral Scientific Research Foundation of Liaoning Province 2019-BS-276
Science and Technology Program of Shenyang 19-112-4-103
Youth Support Foundation of China Medical University QGZ2018058
Scientific Fund of Shengjing Hospital 201801
345 Talent Project of Shengjing Hospital 52-30C
Corresponding Author Si-Yu Sun, MD, PhD, Chief Doctor, Doctor, Professor, Department of Gastroenterology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Shenyang 110004, Liaoning Province, China. sun-siyu@163.com
Key Words Pancreatic cancer; Scoparone; Akt1; PI3K/Akt signaling pathway; Bioinformatics analysis; Xenograft tumor
Core Tip To explore the potential antitumor effect of scoparone on pancreatic cancer and the possible molecular mechanism. Target genes of scoparone were determined using the bioinformatics and multiplatform analyses. The effect of scoparone on pancreatic cancer cell proliferation, migration, invasion, cell cycle, and apoptosis was detected. The expression of hub genes was detected using quantitative reverse transcription polymerase chain reaction, and western blotting was used to analyze the molecular mechanism. Xenograft tumor model and immunohistochemistry were used to detect proliferation in vivo. Our findings indicated that scoparone inhibited pancreatic cancer cell proliferation, migration and invasion, and induced cell cycle arrest and apoptosis through the PI3K/Akt signaling pathway.
Publish Date 2021-09-10 12:09
Citation Li N, Yang F, Liu DY, Guo JT, Ge N, Sun SY. Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway. World J Gastrointest Oncol 2021; 13(9): 1164-1183
URL https://www.wjgnet.com/1948-5204/full/v13/i9/1164.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i9.1164
Full Article (PDF) WJGO-13-1164.pdf
Full Article (Word) WJGO-13-1164.docx
Manuscript File 61264_Auto_Edited-ZMG_WangTQ.docx
Answering Reviewers 61264-Answering reviewers.pdf
Audio Core Tip 61264-Audio core tip.m4a
Biostatistics Review Certificate 61264-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61264-Conflict-of-interest statement.pdf
Copyright License Agreement 61264-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 61264-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 61264-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 61264-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 61264-Language certificate.pdf
Peer-review Report 61264-Peer-review(s).pdf
Scientific Misconduct Check 61264-Bing-Wang JL-1.jpg
Scientific Misconduct Check 61264-Scientific misconduct check.pdf
Scientific Editor Work List 61264-Scientific editor work list.pdf