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2/22/2021 12:47:36 PM | Browse: 9 | Download: 12
Publication Name World Journal of Clinical Oncology
Manuscript ID 61570
Country/Territory United States
Received
2020-12-14 15:39
Peer-Review Started
2020-12-14 15:41
To Make the First Decision
Return for Revision
2020-12-24 19:05
Revised
2021-01-04 19:15
Second Decision
2021-01-12 06:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-01-21 22:16
Articles in Press
2021-01-21 22:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-02-01 05:38
Publish the Manuscript Online
2021-02-22 12:47
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses
Manuscript Source Unsolicited Manuscript
All Author List Monica Peravali, Cristiane Gomes-Lima, Eshetu Tefera, Mairead Baker, Mamta Sherchan, Saira Farid, Kenneth Burman, Florina Constantinescu and Irina Veytsman
ORCID
Author(s) ORCID Number
Monica Peravali http://orcid.org/0000-0002-6511-2826
Cristiane Gomes-Lima http://orcid.org/0000-0001-7684-8268
Eshetu Tefera http://orcid.org/0000-0001-5041-8438
Mairead Baker http://orcid.org/0000-0001-54164615
Mamta Sherchan http://orcid.org/0000-0003-2574-2046
Saira Farid http://orcid.org/0000-0001-6499-5543
Kenneth Burman http://orcid.org/0000-0001-8597-7213
Florina Constantinescu http://orcid.org/0000-0003-3978-6226
Irina Veytsman http://orcid.org/0000-0002-9975-3445
Funding Agency and Grant Number
Corresponding Author Monica Peravali, MD, Academic Fellow, Department of Hematology/Oncology, MedStar Washington Hospital Center, 110 Irving Street, Washington, DC 20010, United States. monica.peravali@medstar.net
Key Words Immunotherapy; Adverse events; Endocrine; Survival; Race; Minority
Core Tip Immune checkpoint inhibitors have revolutionized the treatment of many types of cancer, yet they cause various immune-related adverse events (irAEs), notably thyroid dysfunction. Development of irAEs has been reported as a surrogate marker of improved survival. However, minority racial group representation is a limitation in immunotherapy trials. In this retrospective study, we evaluate the association of development of irAEs to survival outcomes in patients treated with immune checkpoint inhibitors for advanced stage solid malignancies. The racial diversity of the population of patients is a unique feature of this study. Our data concluded a positive correlation of irAEs development with increased probability of survival and demonstrates a positive correlation with Caucasian race and overall survival.
Publish Date 2021-02-22 12:47
Citation Peravali M, Gomes-Lima C, Tefera E, Baker M, Sherchan M, Farid S, Burman K, Constantinescu F, Veytsman I. Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses. World J Clin Oncol 2021; 12(2): 103-114
Url https://www.wjgnet.com/2218-4333/full/v12/i2/103.htm
DOI https://dx.doi.org/10.5306/wjco.v12.i2.103
Full Article (PDF) WJCO-12-103.pdf
Full Article (Word) WJCO-12-103.docx
Manuscript File 61570_Auto_Edited_LM.docx
Answering Reviewers 61570-Answering reviewers.pdf
Audio Core Tip 61570-Audio core tip.m4a
Biostatistics Review Certificate 61570-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 61570-Conflict-of-interest statement.pdf
Copyright License Agreement 61570-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 61570-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 61570-Institutional review board statement.pdf
Peer-review Report 61570-Peer-review(s).pdf
Scientific Misconduct Check 61570-Scientific misconduct check.pdf
Scientific Editor Work List 61570-Scientific editor work list.pdf