| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Combination of type IV collagen 7S, albumin concentrations, and platelet count predicts prognosis of non-alcoholic fatty liver disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Miwa Kawanaka, Ken Nishino, Katsunori Ishii, Tomohiro Tanikawa, Noriyo Urata, Mitsuhiko Suehiro, Takako Sasai, Ken Haruma and Hirofumi Kawamoto |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Miwa Kawanaka, MD, PhD, Associate Professor, Department of General Internal Medicine, Kawasaki Medical School, 2-6-1, Nakasange, Kitaku, Okayama 700-8505, Japan. m.kawanaka@med.kawasaki-m.ac.jp |
| Key Words |
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Platelet count; Albumin; Type IV collagen 7S; All-cause mortality |
| Core Tip |
We investigated biomarkers associated with mortality in non-alcoholic fatty liver disease (NAFLD) patients who underwent liver biopsy. Blood biomarkers associated with mortality were platelet count, albumin levels, and type IV collagen 7S levels. In particular, 5-year and 10-year survival rates were reduced for patients with all three factors: platelet counts below 15 × 104/μL, albumin levels below 3.5 g/dL, and type IV collagen 7S levels. In summary, the combination of the three non-invasive biomarkers is a useful predictor of NAFLD prognosis and helps identify patients with NAFLD who are at high risk of death from all causes. |
| Publish Date |
2021-05-20 15:14 |
| Citation |
Kawanaka M, Nishino K, Ishii K, Tanikawa T, Urata N, Suehiro M, Sasai T, Haruma K, Kawamoto H. Combination of type IV collagen 7S, albumin concentrations, and platelet count predicts prognosis of non-alcoholic fatty liver disease. World J Hepatol 2021; 13(5): 571-583 |
| URL |
https://www.wjgnet.com/1948-5182/full/v13/i5/571.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v13.i5.571 |
