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4/29/2021 2:12:02 AM | Browse: 322 | Download: 596
Publication Name World Journal of Gastroenterology
Manuscript ID 62755
Country Norway
Received
2021-01-28 14:11
Peer-Review Started
2021-01-28 14:19
To Make the First Decision
Return for Revision
2021-03-06 07:06
Revised
2021-03-19 19:09
Second Decision
2021-04-19 12:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-22 03:51
Articles in Press
2021-04-22 03:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-04-27 02:38
Publish the Manuscript Online
2021-04-29 02:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Hypophosphatemia after high-dose intravenous iron treatment in patients with inflammatory bowel disease: Mechanisms and possible clinical impact
Manuscript Source Invited Manuscript
All Author List Trond Espen Detlie, Jonas Christoffer Lindstrøm, Marte Eide Jahnsen, Elisabeth Finnes, Heinz Zoller, Bjørn Moum and Jørgen Jahnsen
ORCID
Author(s) ORCID Number
Trond Espen Detlie http://orcid.org/0000-0002-1576-5298
Jonas Christoffer Lindstrøm http://orcid.org/0000-0002-3163-7552
Marte Eide Jahnsen http://orcid.org/0000-0002-0044-4141
Elisabeth Finnes http://orcid.org/0000-0003-3620-2352
Heinz Zoller http://orcid.org/0000-0003-1794-422X
Bjørn Moum http://orcid.org/0000-0002-5884-4543
Jørgen Jahnsen http://orcid.org/0000-0002-0419-2914
Funding Agency and Grant Number
Corresponding Author Trond Espen Detlie, MD, Academic Fellow, Academic Research, Consultant Physician-Scientist, Doctor, Department of Gastroenterology, Akershus University Hospital, Sykehusveien 25, Lørenskog 1478, Norway. t.e.detlie@medisin.uio.no
Key Words Iron deficiency; Hypophosphatemia; Inflammatory bowel disease; Ferric carboxymaltose; Ferric derisomaltose
Core Tip High-dose intravenous iron is an effective treatment for iron deficiency anaemia (IDA) in inflammatory bowel disease (IBD). However, ferric carboxymaltose (FCM) is associated with development of hypophosphatemia. This study of adult IBD patients with IDA investigated the mechanisms and clinical manifestations related to hypophosphatemia after treatment of either FCM or ferric derisomaltose (FDI). The incidence of hypophosphatemia was significantly higher after FCM than FDI, and fibroblast growth factor 23 had a key role, inducing loss of phosphate in the urine along with a significant lowering of 1,25-dihydroxyvitamin D and ionised calcium levels. Short-term clinical impact was not demonstrated.
Publish Date 2021-04-29 02:12
Citation Detlie TE, Lindstrøm JC, Jahnsen ME, Finnes E, Zoller H, Moum B, Jahnsen J. Hypophosphatemia after high-dose intravenous iron treatment in patients with inflammatory bowel disease: Mechanisms and possible clinical impact. World J Gastroenterol 2021; 27(17): 2039-2053
URL https://www.wjgnet.com/1007-9327/full/v27/i17/2039.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i17.2039
Full Article (PDF) WJG-27-2039.pdf
Full Article (Word) WJG-27-2039.docx
Manuscript File 62755_Auto_Edited_LM.docx
Answering Reviewers 62755-Answering reviewers.pdf
Audio Core Tip 62755-Audio core tip.m4a
Biostatistics Review Certificate 62755-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 62755-Conflict-of-interest statement.pdf
Copyright License Agreement 62755-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 62755-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 62755-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 62755-Language certificate.pdf
Supplementary Material 62755-Supplementary material.pdf
Peer-review Report 62755-Peer-review(s).pdf
Scientific Misconduct Check 62755-Bing-Wang JL-1.jpg
Scientific Misconduct Check 62755-Scientific misconduct check.pdf
Scientific Editor Work List 62755-Scientific editor work list.pdf