Publication Name	World Journal of Cardiology
Manuscript ID	6276
Country	Germany

Received	2013-10-11 20:27
Peer-Review Started	2013-10-12 13:58
To Make the First Decision	2013-12-25 18:17
Return for Revision	2013-12-26 16:05
Revised	2014-01-16 04:44
Second Decision	2014-02-19 11:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-02-19 11:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-12 01:02
Typeset the Manuscript	2014-04-23 08:15
Publish the Manuscript Online	2014-04-24 19:19

ISSN	1949-8462 (online)
Open Access
Copyright
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Category	Virology
Manuscript Type	Autobiography
Article Title	Molecular phenotypes of human parvovirus B19 in patients with myocarditis
Manuscript Source	Invited Manuscript
All Author List	C-Thomas Bock, Anja Düchting, Friederike Utta, Eva Brunner, Bui Tien Sy, Karin Klingel, Florian Lang, Meinrad Gawaz, Stephan B Felix and Reinhard Kandolf
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft, Sonderforschungsbereich-Transregio 19 (project B5)
Corresponding Author	C-Thomas Bock, PhD, Director, Professor, Department of Molecular Pathology, University Hospital of Tuebingen, Liebermeisterstr. 8, 72076 Tuebingen, Germany. bockc@rki.de
Key Words	Myocarditis; Dilated cardiomyopathy; Parvovirus B19; B19V-genotypes; B19V co-infection
Core Tip	Human parvovirus B19 (B19V) has recently been shown to be an emerging pathogen for inflammatory cardiomyopathy (iCMP). We showed that B19V replication intermediates could be detected in acute and ongoing myocarditis. B19V-genotypes 1 and 2 were predominant although B19V-genotype 2 was more prevalent in iCMP. Further analyses revealed that B19V-coinfection with other cardiotropic viruses does occur, most frequently with human herpes virus 6 (HHV6). In vitro experiments showed that the HHV6 U94-transactivator element could transactivate the B19V-P6-promoter. We suggest that long-term persistence of B19V DNA in the human heart occurs and that active/reactivated B19V-replication can be associated with iCMP in a viral load and genotype-dependent manner.
Publish Date	2014-04-24 19:19
Citation	Bock CT, Düchting A, Utta F, Brunner E, Sy BT, Klingel K, Lang F, Gawaz M, Felix SB, Kandolf R. Molecular phenotypes of human parvovirus B19 in patients with myocarditis. World J Cardiol 2014; 6(4): 183-195
URL	http://www.wjgnet.com/1949-8462/full/v6/i4/183.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i4.183

Full Article (PDF)	WJC-6-183.pdf
Full Article (Word)	WJC-6-183.doc
Manuscript File	6276-Review.docx
Answering Reviewers	6276-Answering reviewers.pdf
Copyright License Agreement	6276-Copyright assignment.pdf
Peer-review Report	6276-Peer review(s).pdf
Scientific Editor Work List	6276-Scientific editor work list.doc