Publication Name	World Journal of Gastroenterology
Manuscript ID	62997
Country	Brazil

Received	2021-01-22 14:36
Peer-Review Started	2021-01-22 14:40
To Make the First Decision
Return for Revision	2021-02-28 02:44
Revised	2021-03-13 13:43
Second Decision	2021-04-07 12:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-04-07 20:42
Articles in Press	2021-04-07 20:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-04-15 00:47
Publish the Manuscript Online	2021-04-29 02:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Repurposing metformin for the treatment of gastrointestinal cancer
Manuscript Source	Invited Manuscript
All Author List	Ademar Dantas Cunha Júnior, Arinilda Campos Bragagnoli, Felipe Osório Costa and José Barreto Campello Carvalheira
ORCID	Author(s) ORCID Number Ademar Dantas Cunha Júnior http://orcid.org/0000-0001-8112-4766 Arinilda Campos Bragagnoli http://orcid.org/0000-0002-5165-0797 Felipe Osório Costa http://orcid.org/0000-0002-1997-8389 José Barreto Campello Carvalheira http://orcid.org/0000-0002-0136-0943
Funding Agency and Grant Number
Corresponding Author	José Barreto Campello Carvalheira, MD, PhD, Associate Professor, Department of Internal Medicine, Division of Oncology, University of Campinas (UNICAMP), Tessália Vieira Camargo, S/N, Campinas 13083-970, São Paulo, Brazil. jbcc@unicamp.br
Key Words	Antidiabetic treatments; Gastrointestinal tumors; Therapeutic target
Core Tip	Modulation of cell function into the neoplastic and around the microenvironment tissue are possible cancer targets utilized by metformin to raise chemotherapy's anti-tumor outcomes. Herein we review the studies that have demonstrated the likelihood of metformin as chemo and radiosensitizer, in addition to its chemopreventive and direct therapeutic activity in gastrointestinal tumors.
Publish Date	2021-04-29 02:12
Citation	Cunha Júnior AD, Bragagnoli AC, Costa FO, Carvalheira JBC. Repurposing metformin for the treatment of gastrointestinal cancer. World J Gastroenterol 2021; 27(17): 1883-1904
URL	https://www.wjgnet.com/1007-9327/full/v27/i17/1883.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i17.1883

Full Article (PDF)	WJG-27-1883.pdf
Full Article (Word)	WJG-27-1883.docx
Manuscript File	62997_Auto_Edited_LM.docx
Answering Reviewers	62997-Answering reviewers.pdf
Audio Core Tip	62997-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	62997-Conflict-of-interest statement.pdf
Copyright License Agreement	62997-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	62997-Language certificate.pdf
Peer-review Report	62997-Peer-review(s).pdf
Scientific Misconduct Check	62997-Bing-Fan JR-2.png
Scientific Misconduct Check	62997-Bing-Ma YJ-1.jpg
Scientific Misconduct Check	62997-Scientific misconduct check.pdf
Scientific Editor Work List	62997-Scientific editor work list.pdf