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5/10/2021 7:46:10 AM | Browse: 303 | Download: 711
Publication Name World Journal of Gastroenterology
Manuscript ID 63016
Country/Territory Poland
Received
2021-01-26 16:59
Peer-Review Started
2021-01-26 17:03
To Make the First Decision
Return for Revision
2021-02-27 17:25
Revised
2021-03-13 19:53
Second Decision
2021-04-16 13:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-04-21 03:35
Articles in Press
2021-04-21 03:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-04-28 12:22
Publish the Manuscript Online
2021-05-10 07:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Factors influencing the failure of interferon-free therapy for chronic hepatitis C: Data from the Polish EpiTer-2 cohort study
Manuscript Source Invited Manuscript
All Author List Ewa Janczewska, Mateusz Franciszek Kołek, Beata Lorenc, Jakub Klapaczyński, Magdalena Tudrujek-Zdunek, Marek Sitko, Włodzimierz Mazur, Dorota Zarębska-Michaluk, Iwona Buczyńska, Dorota Dybowska, Agnieszka Czauż-Andrzejuk, Hanna Berak, Rafał Krygier, Jerzy Jaroszewicz, Jolanta Citko, Anna Piekarska, Beata Dobracka, Łukasz Socha, Zbigniew Deroń, Łukasz Laurans, Jolanta Białkowska-Warzecha, Olga Tronina, Brygida Adamek, Krzysztof Tomasiewicz, Krzysztof Simon, Malgorzata Pawłowska, Waldemar Halota and Robert Flisiak
ORCID
Author(s) ORCID Number
Ewa Janczewska http://orcid.org/0000-0002-5406-4603
Mateusz Franciszek Kołek http://orcid.org/0000-0001-6470-4830
Beata Lorenc http://orcid.org/0000-0002-6319-9278
Jakub Klapaczyński http://orcid.org/0000-0003-0209-1930
Magdalena Tudrujek-Zdunek http://orcid.org/0000-0002-5640-5432
Marek Sitko http://orcid.org/000-0003-3078-8604
Włodzimierz Mazur http://orcid.org/0000-0001-9023-2670
Dorota Zarębska-Michaluk http://orcid.org/0000-0003-0938-1084
Iwona Buczyńska http://orcid.org/0000-0003-4446-9102
Dorota Dybowska http://orcid.org/0000-0002-1961-8519
Agnieszka Czauż-Andrzejuk http://orcid.org/0000-0002-5753-5589
Hanna Berak http://orcid.org/0000-0002-0844-9158
Rafał Krygier http://orcid.org/0000-0003-3821-6854
Jerzy Jaroszewicz http://orcid.org/0000-0003-0139-4753
Jolanta Citko http://orcid.org/0000-0003-0323-9466
Anna Piekarska http://orcid.org/0000-0002-7188-4881
Beata Dobracka http://orcid.org/0000-0003-3171-4711
Łukasz Socha http://orcid.org/0000-0001-9871-5327
Zbigniew Deroń http://orcid.org/0000-0002-5368-1845
Łukasz Laurans http://orcid.org/0000-0001-5751-7308
Jolanta Białkowska-Warzecha http://orcid.org/0000-0002-2728-3456
Olga Tronina http://orcid.org/0000-0001-9446-5324
Brygida Adamek http://orcid.org/0000-0002-3300-4935
Krzysztof Tomasiewicz http://orcid.org/0000-0001-7868-2708
Krzysztof Simon http://orcid.org/0000-0002-8040-0412
Malgorzata Pawłowska http://orcid.org/0000-0002-6044-0425
Waldemar Halota http://orcid.org/0000-0003-2952-2374
Robert Flisiak http://orcid.org/0000-0003-3394-1635
Funding Agency and Grant Number
Corresponding Author Ewa Janczewska, DSc, MD, PhD, Adjunct Professor, Department of Basic Medical Sciences, The School of Health Sciences in Bytom, Medical University of Silesia, Piekarska 18, Bytom 41-902, Poland. ejanczewska@sum.edu.pl
Key Words Advanced liver disease; Chronic hepatitis C; Direct-acting antiviral drugs; Sustained virologic response; Interferon-free therapy; Antiviral therapy
Core Tip We analyzed factors influencing the failure of direct-acting antiviral drugs (DAAs) in a large, multicenter EpiTer-2 cohort of patients treated across 22 centers. Our findings demonstrate that failure of DAA treatment occurred mainly in patients with liver cirrhosis and deterioration of liver function. Our machine learning analysis further revealed that older age and creatinine and hemoglobin levels also influenced treatment failure, as did viral factors such as genotype 3 and viral load. Thus, in patients with advanced liver disease, individualized therapy (testing for resistance-associated variants, response-guided treatment) should be considered to maximize the chance of achieving a sustained virologic response.
Publish Date 2021-05-10 07:46
Citation Janczewska E, Kołek MF, Lorenc B, Klapaczyński J, Tudrujek-Zdunek M, Sitko M, Mazur W, Zarębska-Michaluk D, Buczyńska I, Dybowska D, Czauż-Andrzejuk A, Berak H, Krygier R, Jaroszewicz J, Citko J, Piekarska A, Dobracka B, Socha Ł, Deroń Z, Laurans Ł, Białkowska-Warzecha J, Tronina O, Adamek B, Tomasiewicz K, Simon K, Pawlowska M, Halota W, Flisiak R. Factors influencing the failure of interferon-free therapy for chronic hepatitis C: Data from the Polish EpiTer-2 cohort study. World J Gastroenterol 2021; 27(18): 2177-2192
URL https://www.wjgnet.com/1007-9327/full/v27/i18/2177.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i18.2177
Full Article (PDF) WJG-27-2177.pdf
Full Article (Word) WJG-27-2177.docx
STROBE Statement 63016-STROBE-Statement-revision.docx
Manuscript File 63016_Auto_Edited_LM.docx
Answering Reviewers 63016-Answering reviewers.pdf
Audio Core Tip 63016-Audio core tip.mp3
Biostatistics Review Certificate 63016-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 63016-Conflict-of-interest statement.pdf
Copyright License Agreement 63016-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 63016-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 63016-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 63016-Language certificate.pdf
Peer-review Report 63016-Peer-review(s).pdf
Scientific Misconduct Check 63016-Bing-Wang JL-1.jpg
Scientific Misconduct Check 63016-Scientific misconduct check.pdf
Scientific Editor Work List 63016-Scientific editor work list.pdf