ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
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For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Retrospective Cohort Study |
Article Title |
Factors influencing the failure of interferon-free therapy for chronic hepatitis C: Data from the Polish EpiTer-2 cohort study
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Manuscript Source |
Invited Manuscript |
All Author List |
Ewa Janczewska, Mateusz Franciszek Kołek, Beata Lorenc, Jakub Klapaczyński, Magdalena Tudrujek-Zdunek, Marek Sitko, Włodzimierz Mazur, Dorota Zarębska-Michaluk, Iwona Buczyńska, Dorota Dybowska, Agnieszka Czauż-Andrzejuk, Hanna Berak, Rafał Krygier, Jerzy Jaroszewicz, Jolanta Citko, Anna Piekarska, Beata Dobracka, Łukasz Socha, Zbigniew Deroń, Łukasz Laurans, Jolanta Białkowska-Warzecha, Olga Tronina, Brygida Adamek, Krzysztof Tomasiewicz, Krzysztof Simon, Malgorzata Pawłowska, Waldemar Halota and Robert Flisiak |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Ewa Janczewska, DSc, MD, PhD, Adjunct Professor, Department of Basic Medical Sciences, The School of Health Sciences in Bytom, Medical University of Silesia, Piekarska 18, Bytom 41-902, Poland. ejanczewska@sum.edu.pl |
Key Words |
Advanced liver disease; Chronic hepatitis C; Direct-acting antiviral drugs; Sustained virologic response; Interferon-free therapy; Antiviral therapy |
Core Tip |
We analyzed factors influencing the failure of direct-acting antiviral drugs (DAAs) in a large, multicenter EpiTer-2 cohort of patients treated across 22 centers. Our findings demonstrate that failure of DAA treatment occurred mainly in patients with liver cirrhosis and deterioration of liver function. Our machine learning analysis further revealed that older age and creatinine and hemoglobin levels also influenced treatment failure, as did viral factors such as genotype 3 and viral load. Thus, in patients with advanced liver disease, individualized therapy (testing for resistance-associated variants, response-guided treatment) should be considered to maximize the chance of achieving a sustained virologic response. |
Publish Date |
2021-05-10 07:46 |
Citation |
Janczewska E, Kołek MF, Lorenc B, Klapaczyński J, Tudrujek-Zdunek M, Sitko M, Mazur W, Zarębska-Michaluk D, Buczyńska I, Dybowska D, Czauż-Andrzejuk A, Berak H, Krygier R, Jaroszewicz J, Citko J, Piekarska A, Dobracka B, Socha Ł, Deroń Z, Laurans Ł, Białkowska-Warzecha J, Tronina O, Adamek B, Tomasiewicz K, Simon K, Pawlowska M, Halota W, Flisiak R. Factors influencing the failure of interferon-free therapy for chronic hepatitis C: Data from the Polish EpiTer-2 cohort study. World J Gastroenterol 2021; 27(18): 2177-2192 |
URL |
https://www.wjgnet.com/1007-9327/full/v27/i18/2177.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v27.i18.2177 |