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8/29/2014 2:41:00 PM | Browse: 510 | Download: 388
Publication Name World Journal of Gastroenterology
Manuscript ID 6383
Country/Territory Ireland
Received
2013-10-15 15:54
Peer-Review Started
2013-10-16 14:52
To Make the First Decision
2013-12-26 11:39
Return for Revision
2013-12-26 18:06
Revised
Second Decision
2014-02-27 11:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-02-27 11:32
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-03-26 18:37
Publish the Manuscript Online
2014-04-14 10:49
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation
Manuscript Source Invited Manuscript
All Author List Chun Seng Lee, Elizabeth J Ryan and Glen A Doherty
Funding Agency and Grant Number
Funding Agency Grant Number
University College Dublin Foundation
Helsinn-Birex Pharmaceuticals
Corresponding author Dr. Glen A Doherty, Centre for Colorectal Disease, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland. glen.doherty@ucd.ie
Key Words Chemotherapy; Diarrhea; Side-effects; Immunogenic cell death; Pro-inflammatory cytokines
Core Tip Many new drugs are available for use in the treatment of colorectal cancer, resulting in improved prognosis, but also more frequent and severe side-effects. In order to implement complex chemotherapy regimens most effectively, a greater understanding of the underlying mechanisms of associated toxicities are required. Different chemotherapeutic agents activate a diverse range of pro-inflammatory pathways culminating in distinct histopathological changes in intestinal mucosa. However, inflammation also has beneficial effects; enhancing anti-tumor immunity. A better understanding of how to manage the gastrointestinal side-effects of chemotherapy allowing for optimal dosing and induction of immunity will further improve outcomes in colorectal cancer.
Publish Date 2014-04-14 10:49
Citation Lee CS, Ryan EJ, Doherty GA. Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation. World J Gastroenterol 2014; 20(14): 3751-3761
Url http://www.wjgnet.com/1007-9327/full/v20/i14/3751.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i14.3751
Full Article (PDF) WJG-20-3751.pdf
Full Article (Word) WJG-20-3751.doc
Manuscript File 6383-Review.docx
Answering Reviewers 6383-Answering reviewers.pdf
Copyright License Agreement 6383-Copyright assignment.pdf
Peer-review Report 6383-Peer review(s).pdf
Scientific Editor Work List 6383-Scientific editor work list.doc