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7/21/2021 9:30:52 AM | Browse: 12 | Download: 31
Publication Name World Journal of Clinical Oncology
Manuscript ID 63832
Country/Territory Russia
2021-02-03 15:15
Peer-Review Started
2021-02-03 15:16
To Make the First Decision
Return for Revision
2021-03-31 04:59
2021-04-04 12:47
Second Decision
2021-06-03 08:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-06-03 12:02
Articles in Press
2021-06-03 12:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-06-13 21:00
Typeset the Manuscript
2021-07-20 04:42
Publish the Manuscript Online
2021-07-21 09:30
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors
Manuscript Source Invited Manuscript
All Author List Evgeny Imyanitov and Anna Sokolenko
Author(s) ORCID Number
Evgeny Imyanitov http://orcid.org/0000-0003-4529-7891
Anna Sokolenko http://orcid.org/0000-0001-6304-1609
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Science and Higher Education of the Russian Federation 15-2020-789
Corresponding Author Evgeny Imyanitov, MD, Professor, Department of Tumor Growth Biology, N.N. Petrov Institute of Oncology, Pesochny, Leningradskaya str. 68, Saint-Petersburg 197758, Russia. evgeny@imyanitov.spb.ru
Key Words BRCA1/2 mutations; platinum-based therapy; Poly (ADP-ribose) polymerase inhibitors; drug resistance; Secondary mutations; Intratumoral heterogeneity; Neoadjuvant therapy
Core Tip BRCA1/2-associated tumors are highly sensitive to platinum compounds and poly (ADP-ribose) polymerase inhibitors, however they eventually acquire resistance to this type of therapy. Restoration of BRCA1/2 function via the second mutation is the most known mechanism of tumor adaptation to the therapeutic pressure. Some studies demonstrate that even chemonaive BRCA1-driven tumors contain a small fraction of BRCA1-proficient cells, suggesting that the loss of the remaining allele of this gene is not the first event in tumor pathogenesis. These pre-existing platinum-resistant cells rapidly repopulate tumor mass during neoadjuvant therapy for ovarian cancer and explain inevitability of the disease relapses after seemingly successful surgical debulking.
Publish Date 2021-07-21 09:30
Citation Imyanitov E, Sokolenko A. Mechanisms of acquired resistance of BRCA1/2-driven tumors to platinum compounds and PARP inhibitors. World J Clin Oncol 2021; 12(7): 544-556
URL https://www.wjgnet.com/2218-4333/full/v12/i7/544.htm
DOI https://dx.doi.org/10.5306/wjco.v12.i7.544
Full Article (PDF) WJCO-12-544.pdf
Full Article (Word) WJCO-12-544.docx
Manuscript File 63832-Review-FilipodiaCL .docx
Answering Reviewers 63832-Answering reviewers.pdf
Audio Core Tip 63832-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 63832-Conflict-of-interest statement.pdf
Copyright License Agreement 63832-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 63832-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate 63832-Language certificate.pdf
Peer-review Report 63832-Peer-review(s).pdf
Scientific Misconduct Check 63832-Bing-Ma YJ-1.jpg
Scientific Misconduct Check 63832-Bing-Liu M-2.png
Scientific Misconduct Check 63832-Scientific misconduct check.pdf
Scientific Editor Work List 63832-Scientific editor work list.pdf