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10/26/2021 8:04:00 AM | Browse: 364 | Download: 634
Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 64238
Country/Territory China
Received
2021-02-14 12:29
Peer-Review Started
2021-02-14 12:34
To Make the First Decision
Return for Revision
2021-03-16 17:14
Revised
2021-03-25 02:10
Second Decision
2021-08-04 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-04 09:02
Articles in Press
2021-08-04 09:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-08-26 03:00
Typeset the Manuscript
2021-10-19 07:31
Publish the Manuscript Online
2021-10-26 08:04
ISSN 1948-9366 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Transplantation
Manuscript Type Scientometrics
Article Title Immunotherapy after liver transplantation: Where are we now?
Manuscript Source Invited Manuscript
All Author List Kin Pan Au and Kenneth Siu Ho Chok
ORCID
Author(s) ORCID Number
Kin Pan Au http://orcid.org/0000-0002-7138-9805
Kenneth Siu Ho Chok http://orcid.org/0000-0001-7921-3807
Funding Agency and Grant Number
Corresponding Author Kenneth Siu Ho Chok, FACS, FRCS (Ed), MBBS, MD, MS, Associate Professor, Department of Surgery and State Key Laboratory for Liver Research, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong NA, China. kennethchok@gmail.com
Key Words Liver transplant; Hepatocellular carcinoma; Recurrence; Immunotherapy; Rejection; Survival
Core Tip A literature review was performed to identify patients with prior liver transplantation and subsequent immunotherapy. Among the 28 included patients, the rejection rate was 32% (n = 9). Patients who developed acute rejection were given immunotherapy earlier after transplantation (median 2.9 years vs 5.3 years, P = 0.02) and their graft biopsies might be more frequently programmed death ligand-1 positive (100% vs 33%, P = 0.053). Among the 19 patients treated for hepatocellular carcinoma (HCC), the overall objective response rate was 11%. Rejection risk is the major obstacle to immunotherapy for post-liver transplant HCC recurrence.
Publish Date 2021-10-26 08:04
Citation Au KP, Chok KSH. Immunotherapy after liver transplantation: Where are we now? World J Gastrointest Surg 2021; 13(10): 1267-1278
URL https://www.wjgnet.com/1948-9366/full/v13/i10/1267.htm
DOI https://dx.doi.org/10.4240/wjgs.v13.i10.1267
Full Article (PDF) WJGS-13-1267.pdf
Full Article (Word) WJGS-13-1267.docx
Manuscript File 64238-Review-FilipodiaCL.docx
Answering Reviewers 64238-Answering reviewers.pdf
Audio Core Tip 64238-Audio core tip.m4a
Biostatistics Review Certificate 64238-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 64238-Conflict-of-interest statement.pdf
Copyright License Agreement 64238-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 64238-Language certificate.pdf
Peer-review Report 64238-Peer-review(s).pdf
Scientific Misconduct Check 64238-Scientific misconduct check.pdf
Scientific Editor Work List 64238-Scientific editor work list.pdf