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8/10/2021 6:48:42 AM | Browse: 263 | Download: 592
Publication Name World Journal of Gastroenterology
Manuscript ID 64478
Country/Territory China
Received
2021-03-04 05:51
Peer-Review Started
2021-03-04 05:54
To Make the First Decision
Return for Revision
2021-05-05 22:14
Revised
2021-05-19 08:46
Second Decision
2021-07-05 12:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-07-05 14:15
Articles in Press
2021-07-05 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-07-26 00:28
Typeset the Manuscript
2021-08-06 10:31
Publish the Manuscript Online
2021-08-10 06:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Neurosciences
Manuscript Type Basic Study
Article Title Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress
Manuscript Source Unsolicited Manuscript
All Author List Jing-Hong Chen, Ying Sun, Pei-Jun Ju, Jin-Bao Wei, Qing-Jie Li and John H Winston
ORCID
Author(s) ORCID Number
Jing-Hong Chen http://orcid.org/0000-0002-7428-9359
Ying Sun http://orcid.org/0000-0002-4076-051X
Pei-Jun Ju http://orcid.org/0000-0003-3554-8810
Jin-Bao Wei http://orcid.org/0000-0002-1302-0022
Qing-Jie Li http://orcid.org/0000-0003-1405-7000
John H Winston http://orcid.org/0000-0003-4220-2236
Funding Agency and Grant Number
Funding Agency Grant Number
NIDDK 5R01DK111819-03
NIDDK 5R01DK032346-28
National Natural Science Foundation of China 81571326
Corresponding Author John H Winston, PhD, Professor, Department of Internal Medicine, University of Texas Medical Branch, 8-104 Med Res Bldg, Galveston, TX 77555, United States. jhwinsto@utmb.edu
Key Words Chronic prenatal stress; Estrogen; Visceral pain; Neuronal sensitization; Excitability; Letrozole
Core Tip We investigated herein whether estrogen re-enhanced visceral hyperalgesia in chronic prenatal stress plus chronic adult stress models. After using physical ovariectomy or chemical inhibitor Letrozole treatment to reduce estrogen levels, we found that the visceral hyperalgesia, colonic afferent neuronal excitability, nerve growth factor & brain-derived neurotrophic factor, and Estrogen all were increased. The findings indicate that the chronic stress induced visceral hypersensitivity is estrogen dependent and the hypersensitivity is estrogen dependent sensitization of primary afferent colon neurons, which provide key scientific evidence in a preclinical model in support of developing gender-based visceral pain management.
Publish Date 2021-08-10 06:48
Citation Chen JH, Sun Y, Ju PJ, Wei JB, Li QJ, Winston JH. Estrogen augmented visceral pain and colonic neuron modulation in a double-hit model of prenatal and adult stress. World J Gastroenterol 2021; 27(30): 5060-5075
URL https://www.wjgnet.com/1007-9327/full/v27/i30/5060.htm
DOI https://dx.doi.org/10.3748/wjg.v27.i30.5060
Full Article (PDF) WJG-27-5060.pdf
Full Article (Word) WJG-27-5060.docx
The ARRIVE Guidelines 64478-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 64478_Review-FilipodiaCL.docx
Answering Reviewers 64478-Answering reviewers.pdf
Audio Core Tip 64478-Audio core tip.m4a
Biostatistics Review Certificate 64478-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 64478-Conflict-of-interest statement.pdf
Copyright License Agreement 64478-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 64478-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 64478-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 64478-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 64478-Language certificate.pdf
Peer-review Report 64478-Peer-review(s).pdf
Scientific Misconduct Check 64478-Bing Liu M-1.png
Scientific Misconduct Check 64478-Bing-Fan JR-2.png
Scientific Misconduct Check 64478-Scientific misconduct check.pdf
Scientific Editor Work List 64478-Scientific editor work list.pdf