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10/13/2021 12:57:54 PM | Browse: 15 | Download: 11
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 64637
Country/Territory Russia
Received
2021-02-21 14:56
Peer-Review Started
2021-02-21 14:59
To Make the First Decision
Return for Revision
2021-06-16 02:16
Revised
2021-06-19 11:47
Second Decision
2021-08-24 03:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-24 08:13
Articles in Press
2021-08-24 08:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-09-30 08:31
Publish the Manuscript Online
2021-10-13 12:57
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Molecular testing for colorectal cancer: Clinical applications
Manuscript Source Invited Manuscript
All Author List Evgeny Imyanitov and Ekaterina Kuligina
ORCID
Author(s) ORCID Number
Evgeny Imyanitov http://orcid.org/0000-0003-4529-7891
Ekaterina Kuligina http://orcid.org/0000-0002-2396-6540
Funding Agency and Grant Number
Funding Agency Grant Number
Ministry of Science and Higher Education of the Russian Federation 075-15-2020-789
Corresponding Author Evgeny Imyanitov, DSc, Professor, Department of Tumor Biology, N.N. Petrov Institute of Oncology, Pesochny, St.-Petersburg 197758, Russia. evgeny@imyanitov.spb.ru
Key Words Colorectal cancer; Anti-epidermal growth factor receptor therapy; KRAS; NRAS; BRAF; HER2; Microsatellite instability; MUTYH; Hereditary cancer
Core Tip Molecular genetic analysis is an integral component of colorectal cancer (CRC) management. Comprehensive KRAS and NRAS testing is mandatory for selection of patients for anti-epidermal growth factor receptor (EGFR) therapy. BRAF V600E mutated cancers are responsive to combination of BRAF and EGFR inhibitors. CRCs with HER2 amplification and overexpression can be controlled by the down-regulation of this receptor. Immune therapy is highly effective in CRCs with exceptionally high tumor mutation burden, e.g., in cancers with microsatellite instability, MUTYH gene inactivation or mutations in the POLE gene. CRC patients with early disease onset, specific tumor features or family history of the disease require germ-line DNA testing.
Publish Date 2021-10-13 12:57
Citation Imyanitov E, Kuligina E. Molecular testing for colorectal cancer: Clinical applications. World J Gastrointest Oncol 2021; 13(10): 1288-1301
URL https://www.wjgnet.com/1948-5204/full/v13/i10/1288.htm
DOI https://dx.doi.org/10.4251/wjgo.v13.i10.1288
Full Article (PDF) WJGO-13-1288.pdf
Full Article (Word) WJGO-13-1288.docx
Manuscript File 64637_Auto_Edited-JLW.docx
Answering Reviewers 64637-Answering reviewers.pdf
Audio Core Tip 64637-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 64637-Conflict-of-interest statement.pdf
Copyright License Agreement 64637-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 64637-Grant application form(s).pdf
Peer-review Report 64637-Peer-review(s).pdf
Scientific Misconduct Check 64637-Scientific misconduct check.pdf
Scientific Editor Work List 64637-Scientific editor work list.pdf