Publication Name	World Journal of Diabetes
Manuscript ID	65031
Country	Canada

Received	2021-02-26 16:45
Peer-Review Started	2021-02-26 16:55
To Make the First Decision
Return for Revision	2021-04-20 18:33
Revised	2021-04-24 06:54
Second Decision	2021-08-13 02:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-08-13 06:28
Articles in Press	2021-08-13 06:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-09-01 09:16
Publish the Manuscript Online	2021-09-07 08:15

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Holistic perspective of the role of gut microbes in diabetes mellitus and its management
Manuscript Source	Invited Manuscript
All Author List	Kannayiram Alagiakrishnan and Tyler Halverson
ORCID	Author(s) ORCID Number Kannayiram Alagiakrishnan http://orcid.org/0000-0003-1444-2451 Tyler Halverson http://orcid.org/0000-0001-5841-7659
Funding Agency and Grant Number
Corresponding Author	Kannayiram Alagiakrishnan, FRCPC, MD, Full Professor, Department of Medicine, University of Alberta, B139-152 University Hospital Clinical Sciences Building, Edmonton T6G 2G3, Alberta, Canada. kalagiakri@aol.com
Key Words	Probiotics; Prebiotics; Synbiotics; Diabetes mellitus; Microbial dysbiosis; Antidiabetic drugs
Core Tip	The emerging role of the gut microbiome on diabetes development, progression as well as prevention has been discussed in this manuscript. The significance of gut dysbiosis in the aetiopathogenesis of diabetes mellitus and its complications has been reviewed. A bidirectional relationship exists between the antidiabetic drugs and the gut microbiome. Faecal transplantation, and bariatric surgery, typically used to treat morbid obesity, have also been shown to improve commensal gut microbiota changes. Diabetic outcomes and management can improve with better understanding of the drug-gut microbiome interactions. There is emerging evidence pointing out that gut biotics can be an add-on therapy with the antidiabetic management. To our knowledge, there is no evidence about the role of gut microbes of diabetic patients who had pancreatic cell transplantation, as well as the role of gut biotics influencing the management in this group.
Publish Date	2021-09-07 08:15
Citation	Alagiakrishnan K, Halverson T. Holistic perspective of the role of gut microbes in diabetes mellitus and its management. World J Diabetes 2021; 12(9): 1463-1478
URL	https://www.wjgnet.com/1948-9358/full/v12/i9/1463.htm
DOI	https://dx.doi.org/10.4239/wjd.v12.i9.1463

Full Article (PDF)	WJD-12-1463.pdf
Full Article (Word)	WJD-12-1463.docx
Manuscript File	65031_Auto_Edited-JPY.docx
Answering Reviewers	65031-Answering reviewers.pdf
Audio Core Tip	65031-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	65031-Conflict-of-interest statement.pdf
Copyright License Agreement	65031-Copyright license agreement.pdf
Peer-review Report	65031-Peer-review(s).pdf
Scientific Misconduct Check	65031-Scientific misconduct check.pdf
Scientific Editor Work List	65031-Scientific editor work list.pdf