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11/24/2021 9:54:22 AM | Browse: 11 | Download: 13
Publication Name World Journal of Hepatology
Manuscript ID 65871
Country/Territory United States
2021-03-17 03:19
Peer-Review Started
2021-03-17 03:52
To Make the First Decision
Return for Revision
2021-05-02 04:50
2021-07-05 23:53
Second Decision
2021-09-22 03:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-23 07:31
Articles in Press
2021-09-23 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-18 03:18
Publish the Manuscript Online
2021-11-24 09:54
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Endocrinology and Metabolism
Manuscript Type Review
Article Title Newly discovered endocrine functions of the liver
Manuscript Source Invited Manuscript
All Author List Jane Rhyu and Run Yu
Author(s) ORCID Number
Jane Rhyu http://orcid.org/0000-0003-0407-4907
Run Yu http://orcid.org/0000-0003-2901-5102
Funding Agency and Grant Number
Corresponding Author Run Yu, MD, PhD, Professor, Division of Endocrinology, Diabetes, and Metabolism, UCLA David Geffen School of Medicine, 200 Medical Plaza Driveway #530, Los Angeles, CA 90095, United States. runyu@mednet.ucla.edu
Key Words Liver; Endocrine function; Hormone; Amino acids; Hepatokine; Fibroblast growth factor 21
Core Tip The liver has many newly discovered endocrine functions, most of which are in regulating metabolism, underscoring the functioning of the liver as a major metabolic organ. Convincing evidence has shown that the liver regulates endocrine functions in mineral and fuel metabolism, especially in the metabolism of glucose and lipids via hepatokines and amino acids via negative feedback on pancreatic α cells. As research into the endocrine function of the liver is a rapidly evolving field, controversial findings often exist; caution needs to be taken when interpreting novel findings to avoid over-simplification of complex metabolic processes and premature allocation of research resources.
Publish Date 2021-11-24 09:54
Citation Rhyu J, Yu R. Newly discovered endocrine functions of the liver. World J Hepatol 2021; 13(11): 1611-1628
URL https://www.wjgnet.com/1948-5182/full/v13/i11/1611.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i11.1611
Full Article (PDF) WJH-13-1611.pdf
Full Article (Word) WJH-13-1611.docx
Manuscript File 65871_Auto_Edited.docx
Answering Reviewers 65871-Answering reviewers.pdf
Audio Core Tip 65871-Audio core tip
Conflict-of-Interest Disclosure Form 65871-Conflict-of-interest statement.pdf
Copyright License Agreement 65871-Copyright license agreement.pdf
Supplementary Material 65871-Copyright permission.eml
Peer-review Report 65871-Peer-review(s).pdf
Scientific Misconduct Check 65871-Bing-Liu M-1.png
Scientific Editor Work List 65871-Scientific editor work list.pdf