| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Microbiology |
| Manuscript Type |
Frontier |
| Article Title |
Frontiers in antibiotic alternatives for Clostridioides difficile infection
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Matthew Phanchana, Phurt Harnvoravongchai, Supapit Wongkuna, Tanaporn Phetruen, Wichuda Phothichaisri, Supakan Panturat, Methinee Pipatthana, Sitthivut Charoensutthivarakul, Surang Chankhamhaengdecha and Tavan Janvilisri |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Cluster (Multi-generation Researchers) Grant, Mahidol University |
MRC-MGR 02/2563 |
|
| Corresponding Author |
Tavan Janvilisri, PhD, Professor, Department of Biochemistry, Faculty of Science, Mahidol University, 272 Rama VI Road, Thung Phayathai, Rajdhevi, Bangkok 10400, Thailand. tavan.jan@mahidol.ac.th |
| Key Words |
Bacteriophage; Pharmaceutical; Clostridioides difficile; Alternative therapy; Drug resistance; Fecal microbiota |
| Core Tip |
Clostridioides difficile is considered a threat to public health owing to increases in treatment failure over the past few years. Current antibiotic treatment options are highly limited. Therefore, alternative strategies are critical. Herein, we review recent advances in alternative therapeutics, including the development of new chemical entities, fecal microbiota transplantation, pre- and pro-biotic, antitoxin antibodies, use of bacteriophages, and vaccines. We also highlight the concerns, limitations, and directions for each of these developments. |
| Publish Date |
2021-11-10 07:13 |
| Citation |
Phanchana M, Harnvoravongchai P, Wongkuna S, Phetruen T, Phothichaisri W, Panturat S, Pipatthana M, Charoensutthivarakul S, Chankhamhaengdecha S, Janvilisri T. Frontiers in antibiotic alternatives for Clostridioides difficile infection. World J Gastroenterol 2021; 27(42): 7210-7232 |
| URL |
https://www.wjgnet.com/1007-9327/full/v27/i42/7210.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v27.i42.7210 |
