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11/24/2021 9:54:22 AM | Browse: 10 | Download: 15
Publication Name World Journal of Hepatology
Manuscript ID 66715
Country/Territory India
Received
2021-04-03 10:56
Peer-Review Started
2021-04-03 10:58
To Make the First Decision
Return for Revision
2021-07-06 02:55
Revised
2021-07-15 16:01
Second Decision
2021-09-14 03:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-09-17 02:02
Articles in Press
2021-09-17 02:02
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-11-18 03:30
Publish the Manuscript Online
2021-11-24 09:54
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Role of immune dysfunction in drug induced liver injury
Manuscript Source Invited Manuscript
All Author List Chandrashekaran Girish and Sukumaran Sanjay
ORCID
Author(s) ORCID Number
Chandrashekaran Girish http://orcid.org/0000-0003-1777-5120
Sukumaran Sanjay http://orcid.org/0000-0001 8323-8425
Funding Agency and Grant Number
Corresponding Author Chandrashekaran Girish, MSc, PhD, Additional Professor, Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, NA, Puducherry 605006, India. gcnx2005@gmail.com
Key Words Immune dysfunction; Liver damage; Hepatotoxic drugs; Drug-induced liver injury; High mobility group box 1
Core Tip This review demonstrates the critical role of the immune system in the progression of drug-induced liver injury and also in determining the severity of the damage. Drugs affect the normal functioning of hepatocytes through several direct and indirect mechanisms leading to the dysfunctional immune response. The major effector cells in amplifying liver damage are Kupffer cells, monocytes and neutrophils. Genetic predispositions and environmental factors also make individuals vulnerable to immune dysfunction.
Publish Date 2021-11-24 09:54
Citation Girish C, Sanjay S. Role of immune dysfunction in drug induced liver injury. World J Hepatol 2021; 13(11): 1677-1687
URL https://www.wjgnet.com/1948-5182/full/v13/i11/1677.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i11.1677
Full Article (PDF) WJH-13-1677.pdf
Full Article (Word) WJH-13-1677.docx
Manuscript File 66715_Auto_Edited.docx
Answering Reviewers 66715-Answering reviewers.pdf
Audio Core Tip 66715-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 66715-Conflict-of-interest statement.pdf
Copyright License Agreement 66715-Copyright license agreement.pdf
Peer-review Report 66715-Peer-review(s).pdf
Scientific Editor Work List 66715-Scientific editor work list.pdf