| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yosuke Nakao, Hiromitsu Hayashi, Yo-ichi Yamashita, Ofuchi Takashi, Kazuki Matsumura, Norio Uemura, Fumimasa Kitamura, Rumi Itoyama, Toshihiko Yusa, Katsunobu Taki, Tatsunori Miyata, Takaaki Higashi, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai and Hideo Baba |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Hiromitsu Hayashi, FACS, MD, PhD, Surgeon, Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. hhayasi@kumamoto-u.ac.jp |
| Key Words |
Lymph node metastasis; Pancreatic neuroendocrine neoplasms; Risk factor; Tumor size |
| Core Tip |
Among the 82 patients, the percentage with lymph node (LN) metastasis according to the pathological findings was 12% (10/82 cases). The median tumor size was 12 mm (range: 5-90 mm). The median tumor size in the LN-positive group (37 mm) was significantly larger than that in the LN-negative group (12 mm) (P = 0.0001). Multivariate analyses revealed that large tumor size (≥ 20 mm) was an independent risk factor for LN metastasis. In patients with small tumors (≤ 10 mm), LN metastasis was not found. In conclusion, large tumor size (≥ 20 mm) is an independent risk factor for LN metastasis in PNENs. In smaller PNENs (≤ 10 mm), we may be able to choose limited surgery without LN dissection. |
| Publish Date |
2022-06-22 08:29 |
| Citation |
Nakao Y, Hayashi H, Yamashita YI, Takashi O, Matsumura K, Uemura N, Kitamura F, Itoyama R, Yusa T, Taki K, Miyata T, Higashi T, Nakagawa S, Okabe H, Imai K, Baba H. Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms. World J Clin Oncol 2021; 13(6): 520-528 |
| URL |
https://www.wjgnet.com/2218-4333/full/v13/i6/520.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v13.i6.520 |
