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6/22/2022 8:29:42 AM | Browse: 20 | Download: 43
Publication Name World Journal of Clinical Oncology
Manuscript ID 66748
Country/Territory Japan
Received
2021-04-10 08:52
Peer-Review Started
2021-04-10 08:54
To Make the First Decision
Return for Revision
2021-07-06 01:22
Revised
2021-10-24 16:15
Second Decision
2022-05-20 03:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-05-23 01:13
Articles in Press
2022-05-23 01:13
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-02-02 18:02
Typeset the Manuscript
2022-05-31 02:26
Publish the Manuscript Online
2022-06-22 08:29
ISSN 2218-4333 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms
Manuscript Source Invited Manuscript
All Author List Yosuke Nakao, Hiromitsu Hayashi, Yo-ichi Yamashita, Ofuchi Takashi, Kazuki Matsumura, Norio Uemura, Fumimasa Kitamura, Rumi Itoyama, Toshihiko Yusa, Katsunobu Taki, Tatsunori Miyata, Takaaki Higashi, Shigeki Nakagawa, Hirohisa Okabe, Katsunori Imai and Hideo Baba
ORCID
Author(s) ORCID Number
Yosuke Nakao http://orcid.org/0000-0002-6156-1421
Hiromitsu Hayashi http://orcid.org/0000-0002-1832-4287
Yo-ichi Yamashita http://orcid.org/0000-0001-8439-6660
Ofuchi Takashi http://orcid.org/0000-0001-6219-5278
Kazuki Matsumura http://orcid.org/0000-0002-6204-9147
Norio Uemura http://orcid.org/0000-0003-3192-4153
Fumimasa Kitamura http://orcid.org/0000-0002-6717-3788
Rumi Itoyama http://orcid.org/0000-0003-1785-7599
Toshihiko Yusa http://orcid.org/0000-0002-0970-8262
Katsunobu Taki http://orcid.org/0000-0001-6532-5947
Tatsunori Miyata http://orcid.org/0000-0003-4749-4741
Takaaki Higashi http://orcid.org/0000-0002-1034-8671
Shigeki Nakagawa http://orcid.org/0000-0003-3994-4028
Hirohisa Okabe http://orcid.org/0000-0003-3041-7563
Katsunori Imai http://orcid.org/0000-0003-0549-1825
Hideo Baba http://orcid.org/0000-0002-6982-3457
Funding Agency and Grant Number
Corresponding Author Hiromitsu Hayashi, FACS, MD, PhD, Surgeon, Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. hhayasi@kumamoto-u.ac.jp
Key Words Lymph node metastasis; Pancreatic neuroendocrine neoplasms; Risk factor; Tumor size
Core Tip Among the 82 patients, the percentage with lymph node (LN) metastasis according to the pathological findings was 12% (10/82 cases). The median tumor size was 12 mm (range: 5-90 mm). The median tumor size in the LN-positive group (37 mm) was significantly larger than that in the LN-negative group (12 mm) (P = 0.0001). Multivariate analyses revealed that large tumor size (≥ 20 mm) was an independent risk factor for LN metastasis. In patients with small tumors (≤ 10 mm), LN metastasis was not found. In conclusion, large tumor size (≥ 20 mm) is an independent risk factor for LN metastasis in PNENs. In smaller PNENs (≤ 10 mm), we may be able to choose limited surgery without LN dissection.
Publish Date 2022-06-22 08:29
Citation Nakao Y, Hayashi H, Yamashita YI, Takashi O, Matsumura K, Uemura N, Kitamura F, Itoyama R, Yusa T, Taki K, Miyata T, Higashi T, Nakagawa S, Okabe H, Imai K, Baba H. Risk factors for lymph node metastasis in patients with pancreatic neuroendocrine neoplasms. World J Clin Oncol 2021; 13(6): 520-528
URL https://www.wjgnet.com/2218-4333/full/v13/i6/520.htm
DOI https://dx.doi.org/10.5306/wjco.v13.i6.520
Full Article (PDF) WJCO-13-520.pdf
Full Article (Word) WJCO-13-520.docx
Manuscript File 66748_Auto_Edited-LJH-Kerr C-LS.docx
Answering Reviewers 66748-Answering reviewers.pdf
Audio Core Tip 66748-Audio core tip.mp4
Biostatistics Review Certificate 66748-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 66748-Conflict-of-interest statement.pdf
Copyright License Agreement 66748-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 66748-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 66748-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 66748-Language certificate.pdf
Peer-review Report 66748-Peer-review(s).pdf
Scientific Misconduct Check 66748-Bing-Liu JH-2.jpg
Scientific Misconduct Check 66748-CrossCheck.jpg
Scientific Editor Work List 66748-Scientific editor work list.pdf