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10/20/2014 10:04:00 AM | Browse: 505 | Download: 412
Publication Name World Journal of Hematology
Manuscript ID 6702
Country/Territory United States
2013-10-27 11:44
Peer-Review Started
2013-10-28 13:34
To Make the First Decision
2014-01-16 08:24
Return for Revision
2014-01-20 17:56
2014-02-15 03:10
Second Decision
2014-06-18 15:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-06-18 15:28
Articles in Press
2014-06-18 15:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2014-09-28 17:47
Publish the Manuscript Online
2014-10-20 10:04
ISSN 2218-6204 (online)
Open Access
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Hematology
Manuscript Type Autobiography
Article Title Tbl3 encodes a WD40 nucleolar protein with regulatory roles in ribosome biogenesis
Manuscript Source Invited Manuscript
All Author List Jindong Wang and Schickwann Tsai
Funding Agency and Grant Number
Funding Agency Grant Number
St. Perres Fund 11-02011
Corresponding Author Schickwann Tsai, MD PhD Department of Internal Medicine University of Utah 30 North 1900 East, 5C402 Salt Lake City, Utah 84132 U.S.A. schickwann.tsai@hsc.utah.edu
Key Words nucleolus; nucleolar protein; ribosome biogenesis; ribosomal RNA; pre-ribosomal RNA
Core Tip The mouse gene transducin β-like 3 (Tbl3) encodes a protein with thirteen WD40 protein-protein interaction motifs and is the mammalian homologue of yeast utp13. Virtually nothing is known about the function of tbl3. In this report, we provide the first direct evidence that tbl3 is targeted to the nucleoli and plays an important role in regulating the synthesis of the 47S pre-rRNA, i.e. at very early stages of ribosome biogenesis. This activity has never been described before and sets tbl3 apart from all other known nucleolar proteins. TBL3 may provide an attractive target for anti-neoplastic therapy.
Publish Date 2014-10-20 10:04
Citation Wang J, Tsai S. Tbl3 encodes a WD40 nucleolar protein with regulatory roles in ribosome biogenesis. World J Hematol 2014; 3(3): 93-104
URL http://www.wjgnet.com/2218-6204/full/v3/i3/93.htm
DOI http://dx.doi.org/10.5315/wjh.v3.i3.93
Full Article (PDF) WJH-3-93.pdf
Full Article (Word) WJH-3-93.doc
Manuscript File 6702-Review.doc
Answering Reviewers 6702-Answering reviewers.pdf
Biostatistics Review Certificate Biostatistician_Review_Report_20131027034924.docx
Copyright License Agreement 6702-Copyright assignment.pdf
Institutional Review Board Approval Form or Document Ethics_Committee_20131027034848.docx
Non-Native Speakers of English Editing Certificate Editing_Certificate_20131027035145.docx
Peer-review Report 6702-Peer reviews.pdf
Scientific Misconduct Check 6702-CrossCheck.jpg
Scientific Editor Work List 6702-Scientific editor work list.pdf