| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This open-access article was selected by an in-house editor and was fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution-NonCommercial-ShareAlike license (CC BY-NC 4.0), which permits others to distribute, remix, adapt, and build upon this work for non-commercial purposes, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Josieli R Colares, Renata M Hartmann, Elizângela G Schemitt, Sandielly R B Fonseca, Marilda S Brasil, Jaqueline N Picada, Alexandre S Dias, Aline F Bueno, Cláudio A Marroni and Norma P Marroni |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Fundo de Incentivo à Pesquisa e Eventos (FIPE) |
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| Corresponding Author |
Norma P Marroni, PhD, Doctor, Full Professor, Research Scientist, Medical Sciences Program, Universidade Federal do Rio Grande do Sul, Rua Jose Kanan Aranha
, Porto Alegre 90050-170, Brazil. nmarroni@terra.com.br |
| Key Words |
Antioxidants; Secondary biliary cirrhosis; Oxidative stress; Melatonin; Bile duct ligation |
| Core Tip |
The experimental model of secondary biliary cirrhosis, by ligation of the main bile duct, mimics the clinical situation, with biochemical, enzymatic, histological changes, and similar biological, inflammatory, genotoxic markers and oxidative stress triggers. Melatonin, used as an antioxidant therapeutic agent, has been shown to be effective in reversing the changes caused at different levels due to its antioxidant, anti-inflammatory, cytoprotective action, including a reduction in DNA damage, with significant improvement and future therapeutic potential. |
| Publish Date |
2022-01-13 11:55 |
| Citation |
Colares JR, Hartmann RM, Schemitt EG, Fonseca SRB, Brasil MS, Picada JN, Dias AS, Bueno AF, Marroni CA, Marroni NP. Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats. World J Gastroenterol 2022; 28(3): 348-364 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i3/348.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i3.348 |
