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1/13/2022 11:55:40 AM | Browse: 18 | Download: 28
Publication Name World Journal of Gastroenterology
Manuscript ID 67899
Country/Territory Brazil
2021-05-05 15:23
Peer-Review Started
2021-05-05 15:26
To Make the First Decision
Return for Revision
2021-06-12 03:56
2021-06-24 22:51
Second Decision
2022-01-10 05:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-01-10 22:07
Articles in Press
2022-01-10 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-01-11 10:03
Publish the Manuscript Online
2022-01-13 11:55
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This open-access article was selected by an in-house editor and was fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution-NonCommercial-ShareAlike license (CC BY-NC 4.0), which permits others to distribute, remix, adapt, and build upon this work for non-commercial purposes, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats
Manuscript Source Invited Manuscript
All Author List Josieli R Colares, Renata M Hartmann, Elizângela G Schemitt, Sandielly R B Fonseca, Marilda S Brasil, Jaqueline N Picada, Alexandre S Dias, Aline F Bueno, Cláudio A Marroni and Norma P Marroni
Author(s) ORCID Number
Josieli R Colares http://orcid.org/0000-0002-0482-204X
Renata M Hartmann http://orcid.org/0000-0001-8667-517X
Elizângela G Schemitt http://orcid.org/0000-0003-3015-0192
Sandielly R B Fonseca http://orcid.org/0000-0003-2662-5116
Marilda S Brasil http://orcid.org/0000-0002-8420-3045
Jaqueline N Picada http://orcid.org/0000-0003-2360-1557
Alexandre S Dias http://orcid.org/0000-0002-0609-4779
Aline F Bueno http://orcid.org/0000-0001-9382-5914
Cláudio A Marroni http://orcid.org/0000-0002-1718-6548
Norma P Marroni http://orcid.org/0000-0001-7856-7953
Funding Agency and Grant Number
Funding Agency Grant Number
Fundo de Incentivo à Pesquisa e Eventos (FIPE)
Corresponding Author Norma P Marroni, PhD, Doctor, Full Professor, Research Scientist, Medical Sciences Program, Universidade Federal do Rio Grande do Sul, Rua Jose Kanan Aranha , Porto Alegre 90050-170, Brazil. nmarroni@terra.com.br
Key Words Antioxidants; Secondary biliary cirrhosis; Oxidative stress; Melatonin; Bile duct ligation
Core Tip The experimental model of secondary biliary cirrhosis, by ligation of the main bile duct, mimics the clinical situation, with biochemical, enzymatic, histological changes, and similar biological, inflammatory, genotoxic markers and oxidative stress triggers. Melatonin, used as an antioxidant therapeutic agent, has been shown to be effective in reversing the changes caused at different levels due to its antioxidant, anti-inflammatory, cytoprotective action, including a reduction in DNA damage, with significant improvement and future therapeutic potential.
Publish Date 2022-01-13 11:55
Citation Colares JR, Hartmann RM, Schemitt EG, Fonseca SRB, Brasil MS, Picada JN, Dias AS, Bueno AF, Marroni CA, Marroni NP. Melatonin prevents oxidative stress, inflammatory activity, and DNA damage in cirrhotic rats. World J Gastroenterol 2022; 28(3): 348-364
URL https://www.wjgnet.com/1007-9327/full/v28/i3/348.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i3.348
Full Article (PDF) WJG-28-348.pdf
Full Article (Word) WJG-28-348.docx
Manuscript File 67899_Auto_Edited.docx
Answering Reviewers 67899-Answering reviewers.pdf
Audio Core Tip 67899-Audio core tip.m4a
Biostatistics Review Certificate 67899-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 67899-Conflict-of-interest statement.pdf
Copyright License Agreement 67899-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 67899-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 67899-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 67899-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 67899-Language certificate.pdf
Peer-review Report 67899-Peer-review(s).pdf
Scientific Misconduct Check 67899-Bing-Fan JR-2.png
Scientific Editor Work List 67899-Scientific editor work list.pdf