Publication Name	World Journal of Hepatology
Manuscript ID	67957
Country	South Africa

Received	2021-05-07 13:02
Peer-Review Started	2021-05-07 13:06
To Make the First Decision
Return for Revision	2021-06-04 03:53
Revised	2021-06-15 15:43
Second Decision	2021-11-08 03:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-11-15 03:09
Articles in Press	2021-11-15 03:09
Publication Fee Transferred
Edit the Manuscript by Language Editor	2021-11-02 10:25
Typeset the Manuscript	2021-12-13 08:54
Publish the Manuscript Online	2021-12-27 05:24

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Genotype E: The neglected genotype of hepatitis B virus
Manuscript Source	Invited Manuscript
All Author List	Luicer Anne Olubayo Ingasia, Constance Wose Kinge and Anna Kramvis
ORCID	Author(s) ORCID Number Luicer Anne Olubayo Ingasia http://orcid.org/0000-0002-7370-7272 Constance Wose Kinge http://orcid.org/0000-0002-6221-5459 Anna Kramvis http://orcid.org/0000-0001-6006-3765
Funding Agency and Grant Number	Funding Agency Grant Number National Research Foundation (NRF) of South Africa GUN #93516 Deutsche Forschungsgemeinschaft (DFG; English: German Research Foundation) Cancer Association of South Africa (CANSA)
Corresponding Author	Anna Kramvis, BSc, PhD, Director, Professor, Hepatitis Virus Diversity Research Unit, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, Gauteng, South Africa. anna.kramvis@wits.ac.za
Key Words	Hepatitis B virus; Genotype E; Evolution; Clinical significance; Antiviral therapy; Vaccination
Core Tip	Although genotype E was identified more than 20 years ago, and is the most widespread genotype in Africa, it has not been extensively studied. The current knowledge status and gaps in its origin and evolution, natural history of infection, disease progression, response to antiviral therapy and vaccination discussed in this review highlight the urgent need for further more in-depth and large-scale investigations into genotype E, the neglected genotype of hepatitis B virus.
Publish Date	2021-12-27 05:24
Citation	Ingasia LAO, Wose Kinge C, Kramvis A. Genotype E: The neglected genotype of hepatitis B virus. World J Hepatol 2021; 13(12): 1875-1891
URL	https://www.wjgnet.com/1948-5182/full/v13/i12/1875.htm
DOI	https://dx.doi.org/10.4254/wjh.v13.i12.1875

Full Article (PDF)	WJH-13-1875.pdf
Full Article (Word)	WJH-13-1875.docx
Manuscript File	67957_Auto_Edited-CCG-Webster J.docx
Answering Reviewers	67957-Answering reviewers.pdf
Audio Core Tip	67957-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	67957-Conflict-of-interest statement.pdf
Copyright License Agreement	67957-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	67957-Grant application form(s).pdf
Peer-review Report	67957-Peer-review(s).pdf
Scientific Editor Work List	67957-Scientific editor work list.pdf