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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 68343
Country/Territory Slovakia
2021-05-19 22:28
Peer-Review Started
2021-05-19 22:32
To Make the First Decision
Return for Revision
2021-06-16 00:08
2021-06-30 01:40
Second Decision
2021-12-06 03:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-12-08 06:00
Articles in Press
2021-12-08 06:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2021-12-31 04:26
Publish the Manuscript Online
2022-01-11 00:11
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model
Manuscript Source Invited Manuscript
All Author List Fereshteh Asgharzadeh, Alex Tarnava, Asma Mostafapour, Majid Khazaei and Tyler W LeBaron
Author(s) ORCID Number
Fereshteh Asgharzadeh http://orcid.org/0000-0002-8349-3722
Alex Tarnava http://orcid.org/0000-0002-0796-5345
Asma Mostafapour http://orcid.org/0000-0001-8337-2827
Majid Khazaei http://orcid.org/0000-0002-8257-2699
Tyler W LeBaron http://orcid.org/0000-0001-9164-6728
Funding Agency and Grant Number
Funding Agency Grant Number
HRW Natural Health Products Inc. dba Drink HRW
Corresponding Author Tyler W LeBaron, BSc, MSc, N/A, Director, Instructor, N/A, Research Scientist, Centre of Experimental Medicine, Institute for Heart Research Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovak Republic, Bratislava 984104 , Slovakia. lebaront@molecularhydrogeninstitute.com
Key Words Colorectal cancer; Molecular hydrogen; 5-fluorouracil; Oxidative stress; Antioxidants; Inflammation
Core Tip Colorectal cancer is a leading cause of death and is often treated with the chemotherapy drug, 5-fluorouracil (5-FU), which has some unwanted side effects. Molecular hydrogen (H2 gas) has antioxidant, anti-inflammatory, and anti-cancer effects. H2 gas can be dissolved in water to make hydrogen-rich water (HRW). The effects of HRW, 5-FU and the combination of HRW and 5-FU in a colorectal-cancer mouse model were examined. HRW and 5-FU decreased tumor size and weight with the combination being the most effective. In contrast to 5-FU, HRW attenuated oxidative stress and improved antioxidant activity.
Publish Date 2022-01-11 00:11
Citation Asgharzadeh F, Tarnava A, Mostafapour A, Khazaei M, LeBaron TW. Hydrogen-rich water exerts anti-tumor effects comparable to 5-fluorouracil in a colorectal cancer xenograft model. World J Gastrointest Oncol 2022; 14(1): 242-252
URL https://www.wjgnet.com/1948-5204/full/v14/i1/242.htm
DOI https://dx.doi.org/10.4251/wjgo.v14.i1.242
Full Article (PDF) WJGO-14-242.pdf
Full Article (Word) WJGO-14-242.docx
Manuscript File 68343_Auto_Edited.docx
Answering Reviewers 68343-Answering reviewers.pdf
Audio Core Tip 68343-Audio core tip.mp3
Biostatistics Review Certificate 68343-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 68343-Conflict-of-interest statement.pdf
Copyright License Agreement 68343-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 68343-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 68343-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 68343-Institutional review board statement.pdf
Peer-review Report 68343-Peer-review(s).pdf
Scientific Misconduct Check 68343-Bing-Gao CC-1.jpg
Scientific Misconduct Check 68343-Bing-Wang JJ-2.png
Scientific Editor Work List 68343-Scientific editor work list.pdf