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11/24/2021 9:54:22 AM | Browse: 13 | Download: 13
Publication Name World Journal of Hepatology
Manuscript ID 68483
Country/Territory India
Received
2021-05-24 17:26
Peer-Review Started
2021-05-24 17:27
To Make the First Decision
Return for Revision
2021-06-15 18:18
Revised
2021-06-30 11:08
Second Decision
2021-08-17 03:30
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2021-08-18 06:41
Articles in Press
2021-08-18 06:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
2021-08-31 04:03
Typeset the Manuscript
2021-11-19 00:40
Publish the Manuscript Online
2021-11-24 09:54
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Mitochondrial hepatopathy: Respiratory chain disorders- ‘breathing in and out of the liver’
Manuscript Source Invited Manuscript
All Author List Amrit Gopan and Moinak S Sarma
ORCID
Author(s) ORCID Number
Amrit Gopan http://orcid.org/0000-0001-8344-1298
Moinak S Sarma http://orcid.org/0000-0003-2015-4069
Funding Agency and Grant Number
Corresponding Author Moinak S Sarma, N/A, Associate Professor, DM, Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareilly Road, Lucknow 226014, India. moinaksen@yahoo.com
Key Words Mitochondrial hepatopathy; Respiratory chain defects; Maternal inheritance; Neonatal liver failure; DNA depletion syndrome; Pearson syndrome
Core Tip Liver disease with multi-system involvement should arouse the suspicion for mitochondrial respiratory chain hepatopathies. These disorders are predominantly autosomal recessive with some having a maternal inheritance. Presence of lactic acidosis without hypoglycemia is an important clue. A tiered evaluation yields the most with final step being a genetic and enzyme analysis from tissue of interest. Treatment is largely supportive with blood transfusions, correction of acidosis, shock, providing cofactors and salvage therapies, with liver transplantation in a select group. A Periodic follow-up is mandatory for monitoring evolution of disease including “migration” to other systems.
Publish Date 2021-11-24 09:54
Citation Gopan A, Sarma MS. Mitochondrial hepatopathy: Respiratory chain disorders- ‘breathing in and out of the liver’. World J Hepatol 2021; 13(11): 1707-1726
URL https://www.wjgnet.com/1948-5182/full/v13/i11/1707.htm
DOI https://dx.doi.org/10.4254/wjh.v13.i11.1707
Full Article (PDF) WJH-13-1707.pdf
Full Article (Word) WJH-13-1707.docx
Manuscript File 68483-Review-Filipodia-CL.docx
Answering Reviewers 68483-Answering reviewers.pdf
Audio Core Tip 68483-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 68483-Conflict-of-interest statement.pdf
Copyright License Agreement 68483-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 68483-Language certificate.pdf
Peer-review Report 68483-Peer-review(s).pdf
Scientific Misconduct Check 68483-Bing-Gao CC-1.jpg
Scientific Misconduct Check 68483-Bing-Wang JJ-2.jpg
Scientific Misconduct Check 68483-Scientific misconduct check.pdf
Scientific Editor Work List 68483-Scientific editor work list.pdf